Summary

Name TP53
Full Name Cellular tumor antigen p53
Synonyms Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 | P53
Primary ID P04637
Links - -
Type protein
Relations 309
Pathways Acute Myeloid Leukemia, AML1-ETO in AML, DNMT3A in AML, Onco-fusion proteins in AML, IDH-TET in AML, KIT in AML, miRNA in AML, NPM1 in AML, AML_TRIPLETS, Colorectal Carcinoma, EBV infection, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Glycolysis and Gluconeogenesis, Luminal Breast Cancer, Macrophage: IL1 beta, Mitochondrial Control of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), P38 Signaling, Prostate Cancer, p53 in cancer, Pancreatic ductal adenocarcinoma (PDA), Pentose phosphate pathway
Inhibitors 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide; seliciclib
Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png acetylation TP53 0.344
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation TP53 0.493
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation TP53 0.655
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TP53 0.446
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination TP53 0.588
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png neddylation TP53 0.656
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation TP53 0.908
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, p53 in cancer
+ down-regulates img/direct_inhibition.png deacetylation TP53 0.798
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates img/direct-activation.png phosphorylation TP53 0.772
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.764
Publications: 4 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53 0.416
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, Glycolysis and Gluconeogenesis, NPM1_new
+ up-regulates img/direct-activation.png phosphorylation TP53 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.785
Publications: 18 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.582
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.773
Publications: 7 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation TP53 0.752
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.697
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.322
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.839
Publications: 10 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates img/direct_inhibition.png dephosphorylation TP53 0.582
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.764
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, P38 Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.292
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.764
Publications: 6 Organism: Homo Sapiens,
Pathways:FLT3-ITD signaling, P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53 0.748
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.325
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.522
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates img/direct-activation.png phosphorylation TP53 0.427
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.785
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation TP53 0.722
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.708
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.785
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates img/direct-activation.png phosphorylation TP53 0.554
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.292
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation TP53 0.374
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.694
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.374
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.79
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates img/direct-activation.png phosphorylation TP53 0.58
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.576
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.737
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.79
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates img/direct-activation.png phosphorylation TP53 0.417
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.772
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.568
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.603
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, KIT in AML
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.338
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.772
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.804
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.412
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.867
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.556
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.473
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.449
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.44
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.716
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Triple mutant AML
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation TP53 0.407
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.569
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.752
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.473
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.449
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.451
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TP53 0.556
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.804
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TP53 0.548
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.651
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.791
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation TP53 0.659
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.659
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation TP53 0.662
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TP53 0.651
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TP53 0.543
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.518
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.668
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation TP53 0.589
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation TP53 0.569
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.383
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.79
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TP53 0.315
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TP53 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, KIT in AML
+ up-regulates quantity by stabilization img/direct-activation.png binding TP53 0.468
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TP53 0.947
Publications: 1 Organism: In Vitro
+ up-regulates quantity by stabilization img/indirect-activation.png TP53 0.782
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, DNMT3A in AML, Onco-fusion proteins in AML, NPM1 in AML, AML_TRIPLETS, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Malignant Melanoma, Triple mutant AML, NPM1_new
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FNTA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Glycolysis 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PERP 0.625
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png TP53 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, DNMT3A in AML, Onco-fusion proteins in AML, IDH-TET in AML, KIT in AML, miRNA in AML, NPM1 in AML, AML_TRIPLETS, Colorectal Carcinoma, EBV infection, FLT3-ITD in AML, FLT3-ITD signaling, Luminal Breast Cancer, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), P38 Signaling, Prostate Cancer, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/direct-activation.png TP53 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SIAH1 0.386
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.614
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP2 0.464
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BAX 0.742
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma, p53 in cancer
+ up-regulates quantity by stabilization img/direct-activation.png ubiquitination TP53 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation MLH1 0.595
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.873
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates activity img/direct-activation.png binding TP53 0.304
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization TP53 0.572
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/indirect-activation.png TP53 0.536
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation PMS2 0.565
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TP53 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TNFRSF10B 0.636
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation Hexokinase 0.429
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ up-regulates quantity by expression img/indirect-activation.png TP53 0.493
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML, EBV infection, FLT3-ITD signaling, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/direct-activation.png phosphorylation TP53 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, FLT3-ITD signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TP53 0.448
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TBXAS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BAX 0.742
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma, p53 in cancer
+ up-regulates activity img/direct-activation.png acetylation TP53 0.908
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BID 0.497
Publications: 1 Organism: Mus Musculus
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BAX 0.742
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma, p53 in cancer
+ down-regulates img/direct_inhibition.png ubiquitination TP53 0.552
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NLRC4 0.422
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ZNF365 0.297
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HK2 0.429
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TP53 0.968
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, DNMT3A in AML, IDH-TET in AML, miRNA in AML, NPM1 in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Triple mutant AML, NPM1_new, Prostate Cancer, p53 in cancer, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TP53 0.583
Publications: 1
+ up-regulates quantity by stabilization img/direct-activation.png binding TP53 0.341
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FGF2 0.459
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation AIFM2 0.479
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deubiquitination TP53 0.732
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ img/unknown.png ubiquitination TP53 0.619
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation LRBA 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ETS1 0.552
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TP53 0.377
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding TP53 0.338
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BIRC5 0.543
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination TP53 0.646
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TP53 0.316
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation THBS1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ZDHHC5 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RLIM 0.2
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTSD 0.376
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TP53 0.514
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell_death 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TP53 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, KIT in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MDM2 0.968
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, DNMT3A in AML, IDH-TET in AML, miRNA in AML, NPM1 in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Triple mutant AML, NPM1_new, Prostate Cancer, p53 in cancer, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png ubiquitination TP53 0.379
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TP53 0.597
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53 0.272
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation GMPS 0.388
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding G6PD 0.571
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TP53 0.908
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, p53 in cancer
+ down-regulates img/direct_inhibition.png chemical inhibition TP53 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation AIFM1 0.364
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NR4A3 0.269
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2 0.738
Publications: 1
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, KIT in AML, miRNA in AML, AML_TRIPLETS, Colorectal Carcinoma, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), p53 in cancer
+ down-regulates img/direct_inhibition.png deacetylation TP53 0.52
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition TP53 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png TP53 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Mitochondrial Control of Apoptosis, Non-small-cell lung cancer (NSCLC), P38 Signaling, p53 in cancer
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.738
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, KIT in AML, miRNA in AML, AML_TRIPLETS, Colorectal Carcinoma, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), p53 in cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.487
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation TP53 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ABCB1 0.602
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, DNMT3A in AML, Onco-fusion proteins in AML, KIT in AML, miRNA in AML, NPM1 in AML, AML_TRIPLETS, Colorectal Carcinoma, EBV infection, FLT3-ITD in AML, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, P38 Signaling, p53 in cancer, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/indirect-activation.png RPS6KA1 0.37
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates quantity by stabilization img/direct-activation.png polyubiquitination TP53 0.474
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53 0.498
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RPS6K 0.37
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/indirect_inhibition.png TP53 0.253
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.318
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates activity img/direct_inhibition.png binding TP53 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FAS 0.589
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.598
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/indirect-activation.png TP53 0.316
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination TP53 0.476
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.496
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png TP53 0.601
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PMAIP1 0.692
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png acetylation TP53 0.908
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, p53 in cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FNTB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GLS2 0.618
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BAK1 0.676
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Malignant Melanoma, Non-small-cell lung cancer (NSCLC)
+ up-regulates quantity by stabilization img/indirect-activation.png TP53 0.368
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates img/direct-activation.png binding TP53 0.388
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DRAM2 0.315
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png TP53 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.69
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation VCAN 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBP/p300 0.908
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation OGG1 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCNG1 0.782
Publications: 2 Organism: Rattus Norvegicus,
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HR 0.348
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BBC3 0.683
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SCO2 0.626
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAX 0.742
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma, p53 in cancer
+ up-regulates img/indirect-activation.png TP53 0.493
Publications: 1 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53 0.425
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GADD45A 0.649
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ANKRD11 0.316
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.536
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AFP 0.455
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TP53 0.672
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SLC2A1 0.586
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SLC2A4 0.346
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NDRG1 0.507
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.895
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TP53 0.401
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TIGAR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FASLG 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates img/direct-activation.png phosphorylation TP53 0.591
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PHB 0.458
Publications: 1
+ up-regulates img/indirect-activation.png CYCS 0.476
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NOXA1 0.265
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ down-regulates activity img/direct_inhibition.png deacetylation TP53 0.471
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png ubiquitination TP53 0.371
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TP53 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BIRC5 0.543
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png deacetylation TP53 0.798
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CRYAB 0.487
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TP53 0.407
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.397
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NFKB2 0.442
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TP53 0.349
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM4B 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.873
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates activity img/direct-activation.png relocalization TP53 0.582
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Mitochondrial Control of Apoptosis