Summary

Name STAT2
Full Name Signal transducer and activator of transcription 2
Synonyms p113
Primary ID P52630
Links - -
Type protein
Relations 8
Function Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png acetylation STAT2 0.551
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation STAT2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAT2 0.757
Publications: 2 Organism: , Homo Sapiens
+ up-regulates activity img/direct-activation.png binding STAT2 0.918
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding STAT1 0.537
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding STAT2 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding ISGF3 complex 0.728
Publications: 1 Organism: In Vitro