| + |
HCCS | up-regulates activity 
chemical modification
|
CYCS |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280296 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10563795 |
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed. The reaction is coupled to the pumping of four additional protons across the membrane. According to the currently accepted concept, the pumping of all four protons occurs after the binding of oxygen to the reduced enzyme and is exclusively coupled to the last two electron transfer steps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HCCS | up-regulates activity
binding
|
heme b |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280298 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23150584 |
Spectroscopic analyses of HCCS alone and complexes of HCCS with site-directed variants of cytochrome c revealed the fundamental steps of heme attachment and maturation. A conserved histidine in HCCS (His154) provided the key ligand to the heme iron. Formation of the HCCS:heme complex served as the platform for interaction with apocytochrome c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
HCCS
- 
- 