Relation Results

Summary

Name TERF1
Full Name Telomeric repeat-binding factor 1
Synonyms NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1 | PIN2, TRBF1, TRF, TRF1
Primary ID P54274
Links - -
Type protein
Relations 11
Function Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. C ...
View More

Viewer

Type: Score: Layout: SPV 
0.3430.5750.3750.20.20.8030.7520.20.553NEK7TERF1ATMPLK1CSNK2A1TERB1TNKSShelterin complexNCAPH2TNKS2

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ NEK7up-regulates quantity by stabilization img/direct-activation.png phosphorylation TERF1 0.343
Identifier Residue Sequence Organism Cell Line
SIGNOR-273903 Ser114 AIIHGLSsLTACQLR Homo sapiens HeLa Cell
pmid sentence
Mechanistically, Nek7 interacts with and phosphorylates TRF1 on Ser114, which prevents TRF1 from binding to Fbx4, an Skp1-Cul1-F box E3 ligase subunit, thereby alleviating proteasomal degradation of TRF1, leading to a stable association of TRF1 with Tin2 to form a shelterin complex.
Publications: 1 Organism: Homo Sapiens
+ NEK7up-regulates activity img/direct-activation.png phosphorylation TERF1 0.343
Identifier Residue Sequence Organism Cell Line
SIGNOR-278447 Ser114 AIIHGLSsLTACQLR Homo sapiens
pmid sentence
Using KR-TRF2 to induce telomeric DNA damage, we found that TRF1 degradation was also exacerbated when ATM was inhibited after damage induction (55.2% of mock treated cells) (XREF_FIG), indicating that the ATM signal pathway is required for Nek7 mediated TRF1 stabilization.|We show that Nek7 phosphorylates TRF1 at Ser114 and in turn maintains stability of the shelterin complex at telomeres.
Publications: 1 Organism: Homo Sapiens
+ NEK7up-regulates quantity img/direct-activation.png phosphorylation TERF1 0.343
Identifier Residue Sequence Organism Cell Line
SIGNOR-278448 Ser114 AIIHGLSsLTACQLR Homo sapiens
pmid sentence
Furthermore, we found that Nek7 overexpression could enhance TRF1 protein expression (XREF_FIG), suggesting that Nek7 may regulate TRF1 expression either at the transcription or posttranscriptional levels.|We show that Nek7 phosphorylates TRF1 at Ser114 and in turn maintains stability of the shelterin complex at telomeres.
Publications: 1 Organism: Homo Sapiens
+ ATMup-regulates activity img/direct-activation.png phosphorylation TERF1 0.575
Identifier Residue Sequence Organism Cell Line
SIGNOR-108419 Ser219 SKLLMIIsQKDTFHS Homo sapiens HeLa Cell
pmid sentence
Telomeric protein pin2/trf1 as an important atm target in response to double strand dna breaks. activated atm directly phosphorylated pin2/trf1 preferentially on the conserved ser(219)-gln site in vitro and in vivo.
Publications: 1 Organism: Homo Sapiens
+ PLK1up-regulates img/direct-activation.png phosphorylation TERF1 0.375
Identifier Residue Sequence Organism Cell Line
SIGNOR-179461 Ser435 KKLKLISsDSED Homo sapiens
pmid sentence
Plk1 phosphorylation of trf1 is essential for its binding to telomeres
Publications: 1 Organism: Homo Sapiens
+ CSNK2A1up-regulates img/direct-activation.png phosphorylation TERF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-178034 Thr122 LTACQLRtIYICQFL Homo sapiens
pmid sentence
Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation. Mapping of the ck2 target site identified threonine 122 as a substrate in trf1. A threonine to alanine change at this position led to a diminished dna binding due to reduced dimerization of trf1.
Publications: 1 Organism: Homo Sapiens
+ TERB1up-regulates activity img/direct-activation.png relocalization TERF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263315 Homo sapiens HEK-293 Cell
pmid sentence
The shelterin complex has six proteins, containing TRF1, TRF2, POT1, RAP1, TIN2, and TPP1. The shelterin complex is localized to the chromosome end and protects telomeric DNA (Palm and de Lange, 2008). The TTM complex acts as a “linker” and bridges the LINC and shelterin complexes together. The connection between TTM and shelterin complexes is well-known, which is mediated by TERB1 and TRF1
Publications: 1 Organism: Homo Sapiens
+ TNKSdown-regulates activity img/direct_inhibition.png ADP-ribosylation TERF1 0.803
Identifier Residue Sequence Organism Cell Line
SIGNOR-263377 in vitro
pmid sentence
Tankyrase 1 ADP-ribosylates TRF1, inhibiting its binding to telomeric DNA.
Publications: 1 Organism: In Vitro
+ TERF1form complex img/form-complex.png binding Shelterin complex 0.752
Identifier Residue Sequence Organism Cell Line
SIGNOR-263316 Homo sapiens
pmid sentence
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins|Gel filtration reveals a complex consisting of POT1 , RAP1, TRF1, ACD, TERF2 and TINF2 proteins.
Publications: 1 Organism: Homo Sapiens
+ NCAPH2up-regulates activity img/direct-activation.png binding TERF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263914 Homo sapiens HeLa Cell
pmid sentence
Taken together these observations suggest that NCAPH2 promotes telomere stability, possibly through a direct interaction with the TRF1 shelterin component, and prevents telomere dysfunction resulting from impaired DNA replication.
Publications: 1 Organism: Homo Sapiens
+ TNKS2down-regulates activity img/direct_inhibition.png ADP-ribosylation TERF1 0.553
Identifier Residue Sequence Organism Cell Line
SIGNOR-263376 in vitro
pmid sentence
Tankyrase 2 poly(ADP-ribosyl)ated itself and TRF1. Overexpression of tankyrase 2 in the nucleus released endogenous TRF1 from telomeres.
Publications: 1 Organism: In Vitro
a simple tooltip