| + |
PTPN5 | up-regulates activity 
dephosphorylation
|
BAK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248542 |
Tyr108 |
QPTAENAyEYFTKIA |
Homo sapiens |
|
| pmid |
sentence |
| 20959805 |
In this study, we report that on apoptotic stimulation Bak undergoes dephosphorylation at tyrosine residue 108 (Y108), a critical event that is necessary but not sufficient for Bak activation, but is required both for early exposure of the occluded N-terminal domain and multimerisation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN5 | down-regulates activity 
dephosphorylation
|
GRIN2B |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276991 |
Tyr1474 |
GSSNGHVyEKLSSIE |
Homo sapiens |
|
| pmid |
sentence |
| 19625523 |
In addition, STEP 61 dephosphorylates the tyr 1472 on the NR2B subunit of the NMDAR, which promotes internalization of the NMDAR complex. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265744 |
Tyr1474 |
GSSNGHVyEKLSSIE |
Mus musculus |
Cerebral Cortical Neuron |
| pmid |
sentence |
| 20427654 |
These previous results, together with the present findings, indicate that STEP61 dephosphorylates the NR2B subunit at its regulatory tyr1472 site, and dephosphorylation of this site leads to internalization of the NMDAR complex from neuronal surface membranes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
PTPN5 | up-regulates activity
dephosphorylation
|
MOB1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277058 |
Tyr26 |
IPEGSHQyELLKHAE |
Homo sapiens |
|
| pmid |
sentence |
| 28675297 |
PTPN5 dephosphorylates\nMob1a at Y26 residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN5 | down-regulates
dephosphorylation
|
FYN |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86791 |
Tyr420 |
RLIEDNEyTARQGAK |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11983687 |
Wild-type step(61) dephosphorylates fyn at tyr(420) but not at tyr(531). These results suggest that step regulates the activity of fyn by specifically dephosphorylating the regulatory tyr(420) and may be one mechanism by which fyn activity is decreased within psds. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
PTPN5 | down-regulates activity
dephosphorylation
|
GRIN2A |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277089 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27857196 |
STEP inhibition by TC-2153 enhanced Tyr phosphorylation of GluN2A (XREF_FIG, 1 EGTA+TC-2153, n = 5, P < 0.05 compared with 1mM EGTA) without altering phosphorylation of Src (XREF_FIG, 1 EGTA+TC-2153, n = 5, P> 0.05 compared with 1 EGTA).|These findings confirm that not only GluN2B and Fyn but also GluN2A are substrates of STEP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN5 | down-regulates activity
dephosphorylation
|
GRIA2 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277040 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21883219 |
One study showed that stimulation of the metabotrophic glutamate receptor mGluR5 leads to a STEP mediated tyrosine dephosphorylation of GluA2 and internalization of GluA1 and GluA2, although the tyrosine residue on GluA2 that is dephosphorylated by STEP remains unidentified. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN5 | up-regulates
binding
|
MAPK14 |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-194829 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 23932588 |
First [] step prevents upstream activating kinases from promiscuously binding and activating p38a. Second, by blocking access to the mapk insert pocket, through the stepcat interaction, step can prevent the binding of allosteric signaling molecules that induce autoactivation of p38a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
PTPN5
- 
- 