| + |
PRKCA | up-regulates 
phosphorylation
|
CDKN2D |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197285 |
Ser76 |
VQDTSGTsPVHDAAR |
Homo sapiens |
|
| pmid |
sentence |
| 22558186 |
Cdk2 and pka were found to participate in p19ink4d phosphorylation process and that they would mediate serine 76 and threonine 141 modifications respectively. Nuclear translocation of p19ink4d induced by dna damage was shown to be dependent on serine 76 phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197289 |
Thr141 |
RRDARGLtPLELALQ |
Homo sapiens |
|
| pmid |
sentence |
| 22558186 |
Cdk2 and pka were found to participate in p19ink4d phosphorylation process and that they would mediate serine 76 and threonine 141 modifications respectively.we propose a sequential phosphorylation model for p19 in which modification at s76 would enable a second phosphorylation event at t141. The phosphorylation-induced structural changes could have functional implicancies for p19 in the dna damage response |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK2 | up-regulates
phosphorylation
|
CDKN2D |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197270 |
Ser76 |
VQDTSGTsPVHDAAR |
Homo sapiens |
|
| pmid |
sentence |
| 22558186 |
Cdk2 and pka were found to participate in p19ink4d phosphorylation process and that they would mediate serine 76 and threonine 141 modifications respectively. Nuclear translocation of p19ink4d induced by dna damage was shown to be dependent on serine 76 phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197274 |
Thr141 |
RRDARGLtPLELALQ |
Homo sapiens |
|
| pmid |
sentence |
| 22558186 |
Cdk2 and pka were found to participate in p19ink4d phosphorylation process and that they would mediate serine 76 and threonine 141 modifications respectively.we propose a sequential phosphorylation model for p19 in which modification at s76 would enable a second phosphorylation event at t141. The phosphorylation-induced structural changes could have functional implicancies for p19 in the dna damage response |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity by expression 
transcriptional regulation
|
CDKN2D |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252918 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17873901 |
Foxo1a strongly activated p15ink4b transcription and p19ink4d transcription, while foxo3a showed higher p19ink4d transcription activity than p15ink4b transcription activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN2D |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157839 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17873901 |
Foxo1a strongly activated p15ink4b transcription and p19ink4d transcription, while foxo3a showed higher p19ink4d transcription activity than p15ink4b transcription activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT3A | down-regulates quantity by repression 
transcriptional regulation
|
CDKN2D |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261510 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26350239 |
Quantitative real-time PCR (qPCR) was used to investigate the effect of DNMT3A on p18INK4C expression, along with the other INK4 members, including p15INK4B, p16INK4A and p19INK4D. The results showed that the depletion of DNMT3A increased the transcriptional levels of the four members of the INK4 family |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDKN2D
- 
- 