Summary

Name FOXO
Primary ID SIGNOR-PF27
Type protein family
Formed by FOXO1, FOXO3, FOXO4, FOXO6
Relations 179
Pathways Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, IDH-TET in AML, FLT3-ITD in AML, FLT3-ITD signaling, Myofiber: BMP, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.909
Publications: 7 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO 0.909
Publications: 10 Organism: Homo Sapiens, In Vitro, Mus Musculus
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO 0.909
Publications: 10 Organism: Homo Sapiens, In Vitro, Mus Musculus
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.909
Publications: 6 Organism: Mus Musculus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism
+ up-regulates img/direct-activation.png phosphorylation FOXO 0.672
Publications: 5 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation FOXO 0.705
Publications: 4 Organism: Homo Sapiens
Tissue: Skin
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.638
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.513
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.787
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.757
Publications: 8 Organism: Homo Sapiens, Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.757
Publications: 3
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.909
Publications: 4 Organism: , Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.452
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.696
Publications: 3
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.696
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.397
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates img/direct-activation.png dephosphorylation FOXO 0.412
Publications: 3 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.909
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.583
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.711
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.387
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.465
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.525
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.525
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOXO 0.509
Publications: 7 Organism: Homo Sapiens, Caenorhabditis Elegans
+ up-regulates activity img/direct-activation.png phosphorylation FOXO 0.396
Publications: 7 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, NPM1_new
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.674
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.548
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.534
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.422
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.534
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation FOXO 0.514
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation FOXO 0.2
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation FOXO 0.705
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IGFBP1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.402
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML
+ down-regulates img/indirect_inhibition.png FOXO 0.909
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRIM63 0.2
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXO 0.568
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates activity img/indirect-activation.png transcriptional regulation TRIM63 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PCK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXO 0.509
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FBXO32 0.2
Publications: 3 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png FOXO 0.501
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding FOXO 0.536
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, PI3K/AKT Signaling, Thyroid Hormone Metabolism
+ down-regulates img/indirect_inhibition.png PPARGC1A 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6PC1 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2D 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6P 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deacetylation FOXO 0.909
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell_death 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new
+ down-regulates activity img/direct_inhibition.png relocalization FOXO 0.413
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GK 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Adipogenesis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png binding FOXO 0.7
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation RBL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Muscle_atrophy 0.7
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L11 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png FOXO 0.909
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates img/direct-activation.png phosphorylation FOXO 0.396
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, NPM1_new
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates img/direct-activation.png dephosphorylation FOXO 0.445
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding FOXO 0.909
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Metabolism 0.7
Publications: 1
+ down-regulates img/indirect_inhibition.png FOXO 0.568
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CITED2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.2
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, IDH-TET in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling
+ up-regulates activity img/direct-activation.png deacetylation FOXO 0.909
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FASLG 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.711
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IDH1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, NPM1_new
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deacetylation FOXO 0.38
Publications: 1 Organism: Mus Musculus
Tissue: Muscle