Summary

Name FOXA1
Full Name Hepatocyte nuclear factor 3-alpha
Synonyms HNF-3-alpha, HNF-3A, Forkhead box protein A1, Transcription factor 3A, TCF-3A | HNF3A, TCF3A
Primary ID P55317
Links - -
Type protein
Relations 13
Pathways Prostate Cancer
Function Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NFIB 0.74
Publications: 1 Organism: Homo Sapiens
Tissue: Prostate Gland
+ up-regulates img/direct-activation.png binding NFIX 0.37
Publications: 1 Organism: Homo Sapiens
Tissue: Prostate Gland
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation AR 0.09
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1A 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1B 0.54
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LOXL2 0.53
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT7 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding FOXA1 0.30
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SFTPB 0.12
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Apoptosis
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.20
Publications: 1 Organism: Homo Sapiens