+ |
FOXA1 | up-regulates
binding
|
NFIB |
0.322 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-205027 |
|
|
Homo sapiens |
|
pmid |
sentence |
24801505 |
Androgen receptor (ar) action throughout prostate development and in maintenance of the prostatic epithelium is partly controlled by interactions between ar and forkhead box (fox) transcription factors, particularly foxa1./ Foxa1 is capable of bringing ar and nfix into proximity, indicating that foxa1 facilitates the ar and nfi interaction by bridging the complex. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FOXA1 | up-regulates quantity by expression
transcriptional regulation
|
SFTPB |
0.29 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254181 |
|
|
Homo sapiens |
|
pmid |
sentence |
12161428 |
A homeodomain and a forkhead transcription factor, NKX2.1 and HNF-3, respectively, are known activators of Sp-B transcription |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254171 |
|
|
Homo sapiens |
Lung Epithelial Cell |
pmid |
sentence |
18003659 |
TGF-beta represses transcription of pulmonary surfactant protein-B gene in lung epithelial cells. Repression is mediated by SMAD3 through interactions with NKX2.1 and FOXA1, two key transcription factors that are positive regulators of SpB transcription. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
FOXA1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN1B |
0.331 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-142940 |
|
|
Homo sapiens |
Breast Cancer Cell |
pmid |
sentence |
16331276 |
We identified a foxa1 binding site within the brca1-responsive element of the p27(kip1) promoter and showed that foxa1 activated the promoter alone and in conjunction with brca1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SMAD3 | down-regulates activity
binding
|
FOXA1 |
0.34 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254168 |
|
|
Homo sapiens |
|
pmid |
sentence |
18003659 |
TGF-beta represses transcription of pulmonary surfactant protein-B gene in lung epithelial cells. Repression is mediated by SMAD3 through interactions with NKX2.1 and FOXA1, two key transcription factors that are positive regulators of SpB transcription. In this study, we found that SMAD3 interacts through its MAD domains, MH1 and MH2 with NKX2.1 and FOXA1 proteins. The sites of interaction on NKX2.1 are located within the NH2 and COOH domains, known to be involved in transactivation function. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FOXA1 | up-regulates quantity by expression
transcriptional regulation
|
HSPA1A |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254164 |
|
|
Homo sapiens |
|
pmid |
sentence |
19486887 |
The results showed overexpression of Foxa1 promoted the expression of HSP72, while Foxa1 depletion, induced by antisense oligonucleotides, decreased the expression of HSP72 in MCF-7 cells under normal and heat stress condition. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FOXA1 | up-regulates
binding
|
NFIX |
0.342 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-205082 |
|
|
Homo sapiens |
|
pmid |
sentence |
24801505 |
Androgen receptor (ar) action throughout prostate development and in maintenance of the prostatic epithelium is partly controlled by interactions between ar and forkhead box (fox) transcription factors, particularly foxa1./ Foxa1 is capable of bringing ar and nfix into proximity, indicating that foxa1 facilitates the ar and nfi interaction by bridging the complex. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Prostate Gland |
+ |
FOXA1 | up-regulates
|
Cell_death |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256642 |
|
|
Homo sapiens |
|
pmid |
sentence |
19127412 |
Overexpression of foxa1 promoted apoptosis |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FOXA1 | down-regulates quantity by repression
transcriptional regulation
|
BCL2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-161448 |
|
|
Homo sapiens |
|
pmid |
sentence |
19127412 |
Foxa1 overexpression decreased the expression of bcl2, while foxa1 depletion increased the expression of bcl2 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FOXA1 | up-regulates quantity by expression
transcriptional regulation
|
LOXL2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254166 |
|
|
Homo sapiens |
Esophageal Squamous Cell Carcinoma Cell |
pmid |
sentence |
20043065 |
These results suggest that FOXA1 induces not only KRT7 but also LOXL2 in a subset of poor prognostic ESCCs with metastatic lymph nodes. FOXA1 siRNA treatment of esophageal cancer cells reduced the mRNA level of both KRT7 and a stabilizer of epithelial-mesenchymal transition (EMT) regulator LOXL2, and that both FOXA1 and LOXL2 siRNAs reduced invasion and migration of ESCC cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FOXA1 | up-regulates quantity by expression
transcriptional regulation
|
HSPA1B |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254165 |
|
|
Homo sapiens |
MCF-7 Cell |
pmid |
sentence |
19486887 |
The results showed overexpression of Foxa1 promoted the expression of HSP72, while Foxa1 depletion, induced by antisense oligonucleotides, decreased the expression of HSP72 in MCF-7 cells under normal and heat stress condition. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FOXA1 | up-regulates
|
Apoptosis |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-183153 |
|
|
Homo sapiens |
|
pmid |
sentence |
19127412 |
Overexpression of foxa1 promoted apoptosis |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FOXA1 | down-regulates quantity by repression
transcriptional regulation
|
AR |
0.758 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251541 |
|
|
Homo sapiens |
|
pmid |
sentence |
24875621 |
FOXA1 directly inhibits AR expression and thus the transcription of its target genes. FOXA1 inhibits AR gene expression in prostate cancer. oss of FOXA1 may lead to androgen-independent AR signaling and thus castration-resistant prostate cancer progression. Indeed, we have recently reported that FOXA1 is downregulated in CRPC |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Prostate Cancer |
+ |
FOXA1 | up-regulates quantity by expression
transcriptional regulation
|
KRT7 |
0.286 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254167 |
|
|
Homo sapiens |
Esophageal Squamous Cell Carcinoma Cell |
pmid |
sentence |
20043065 |
These results suggest that FOXA1 induces not only KRT7 but also LOXL2 in a subset of poor prognostic ESCCs with metastatic lymph nodes. FOXA1 siRNA treatment of esophageal cancer cells reduced the mRNA level of both KRT7 and a stabilizer of epithelial-mesenchymal transition (EMT) regulator LOXL2, and that both FOXA1 and LOXL2 siRNAs reduced invasion and migration of ESCC cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |