| + |
STAT5A | down-regulates 
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256663 |
|
|
Homo sapiens |
Lymphoid Cell |
| pmid |
sentence |
| 14530308 |
Specific inhibition of Stat5a/b promotes apoptosis of IL-2-responsive primary and tumor-derived lymphoid cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 8 complex | up-regulates 
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256641 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Downstream of caspase-8 activation, apoptosis induction takes place |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCL2 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256637 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1286168 |
Bcl-2 functions to inhibit apoptosis in a variety of in vitro and in vivo experiments, suggesting interference with a central mechanism of apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256548 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Caspase-3 is responsible for apoptosis execution |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HK2 | down-regulates activity
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259979 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16892090 |
HK II via its mitochondrial location also suppresses the death of cancer cells, thus increasing their possibility for metastasis and the ultimate death of the human host |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXL2 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256643 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16153597 |
We observed that foxl2 induces apoptosis in the ovarian cells unveiling a novel function of foxl2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
NfKb-p65/p50 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22021368 |
Once genetic mutation of AML1 occurs in hematopoietic cells, aberrant activation of NF-κB signaling exerts antiapoptotic and proliferation-promoting effects via activation of BCL-XL or JUNB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256645 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PML | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256659 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 15093545 |
The promyelocytic leukemia (pml) protein is a potent growth suppressor and proapototic factor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
miR-495 | up-regulates
|
Cell_death |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255801 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26055960 |
Our results suggest that activating mutation of FLT3 in AML can lead, through the induction of JUN, to an increased expression of miR-155, which then causes down-regulation of SPI1 and CEBPB and consequently may causes block of myeloid differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCA | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256660 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 15730925 |
PKC-alpha asODN (antisense oligonucleotides) could inhibit the growth and proliferation of HepG2 and induce its apoptosis by blocking the cell signal transduction related to PKC-alpha in vitro, and may be potentially used in the prevention and management of recurrent and metastatic HCC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIM1 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256657 |
|
|
|
|
| pmid |
sentence |
| 16146838 |
The results of 2 microarray experiments demonstrated that the aberrant activation of STAT proteins by Flt3-ITDs resulted in the up-regulation of several STAT5-responsive genes, such as Pim-1, Pim-2, and members of the SOCS (suppressor of cytokine signaling) protein family. These results are particularly interesting because recent data point to an important role of Pim kinases in the antiapoptosis of hematopoietic cells. |
|
| Publications: |
1 |
| + |
NFE2L2 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256652 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 26194347 |
Nrf2 was up-regulated in HCC, and expression of Nrf2 was correlated with tumor differentiation, metastasis, and tumor size. Further studies demonstrated that inhibition of Nrf2 expression inhibited proliferation by inducing apoptosis and repressed invasion, and up-regulation of Nrf2 expression resulted in opposite phenotypes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEIS1 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256648 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 19109563 |
To discern the mechanisms by which Meis1 inhibition leads to reduced cell growth, we performed cell-cycle and apoptosis analyses.Meis1 knockdown also resulted in increased apoptosis, as evidenced by increased uptake of PI and a stain for activated caspases (CaspaTag) by M26-transduced cells compared with control cells. These results indicate that Meis1 is required for proliferation and survival of 4166 leukemia cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
Yap and taz are two main downstream effectors of the hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256644 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASP3 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256638 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Caspase-3 is responsible for apoptosis execution |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24212651 |
P53 is a nuclear transcription factor with a pro-apoptotic function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAE1 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256651 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25568892 |
Overexpression of AppBp1 in primary neurons induces apoptosis through the neddylation pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hexokinase | down-regulates activity
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270309 |
|
|
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 16892090 |
HK II via its mitochondrial location also suppresses the death of cancer cells, thus increasing their possibility for metastasis and the ultimate death of the human host |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TP73 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
Like p53, its homolog p73 transactivates proapoptotic genes and induces cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NGFR | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256655 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14699954 |
Neurotrophin binding to p75ntr has also been shown to induce apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXA1 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256642 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19127412 |
Overexpression of foxa1 promoted apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLAG1 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256658 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11888928 |
Plagl1 has been shown to prevent the proliferation of tumor cells by inducing cell cycle arrest and apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HLF | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256647 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23415677 |
Ectopic hlf expression inhibits apoptosis in murine and human cells, suggesting that hlf is regulating a conserved transcriptional program that inhibits cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL-AF4 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256650 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 21389315 |
Consequently, cell cycle and apoptosis analyses suggest that MLL-AF4 conveys a selective proliferation coupled to a survival advantage, which correlates with changes in the expression of genes involved in apoptosis, sensing DNA damage and DNA repair. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASP8 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256639 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Downstream of caspase-8 activation, apoptosis induction takes place |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
QRICH1 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33384352 |
QRICH1 promotes cell death and its translation is upregulated by the PERK-eIF2α axis under ER stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIP1 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256646 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11007801 |
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NODAL | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256656 |
|
|
Homo sapiens |
Epithelial Ovarian Cancer Cell |
| pmid |
sentence |
| 15531507 |
Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIL3 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256653 |
|
|
Mus musculus |
Pro-B-lymphocyte |
| pmid |
sentence |
| 10082541 |
NFIL3 inhibits apoptosis without affecting Bcl-xL expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TRAF7 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15001576 |
Overexpression of traf7 induced caspase-dependent apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
Yap and taz are two main downstream effectors of the hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM27 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
Here we show that ectopic expression of rfp in human embryonic kidney 293 cells causes extensive apoptosis, as assessed by multiple criteria. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
3.0
Cell_death