| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270629 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30765414 |
The major spliceosomal building blocks are the U1, U2, U4/U6, and U5 small nuclear ribonucleoproteins (snRNPs). Each consists of a small nuclear RNA (snRNA) (or two, in the case of U4/U6), seven Sm proteins that form a ring (or seven Lsm proteins in the case of U6), and a variable number of snRNP-specific proteins (Fig. 1F) (Will and Lührmann 2011). Under splicing conditions, the U4/U6 and U5 snRNPs form a 25S U4/U6.U5 tri-snRNP, in which the U4 and U6 snRNAs are base-paired, forming a three-way junction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280837 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29414516 |
The small subunit processome is the first precursor of the small eukaryotic ribosomal subunit. Eukaryotic ribosome biogenesis is initiated by the seven-subunit UtpA complex (Utp4, Utp5, Utp8, Utp9, Utp10, Utp15 & Utp17). UtpA binding and the presence of additional parts of the 5′ ETS appear to be required for the subsequent recruitment of the six-subunit UtpB complex (Utp1/Pwp2, Utp6, Utp12, Utp13, Utp18 & Utp21) and the U3 snoRNP (U3 snoRNA, Nop1/fibrillarin, Snu13, Nop56 & Nop58) |
|