Summary

Name WNT4
Full Name Protein Wnt-4
Synonyms WNT4_HUMAN
Primary ID P56705
Links - -
Type protein
Relations 6
Function Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/indirect_inhibition.png WNT4 0.285
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png MYOD1 0.321
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding WNT4 0.723
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png binding LRP5 0.636
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MYF5 0.301
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding LRP6 0.634
Publications: 1 Organism: Homo Sapiens