Relation Results

Summary

Name BACE1
Full Name Beta-secretase 1
Synonyms Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 | BACE, KIAA1149
Primary ID P56817
Links - -
Type protein
Relations 10
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between r ...
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Type: Score: Layout: SPV 
0.7940.4520.3680.3770.4440.380.5260.258BACE1APPUSP8CSNK1DCDK5/CDK5R1CDK5STUB1FBXO2Cullin 1-RBX1-Skp1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ BACE1up-regulates activity img/direct-activation.png cleavage APP 0.794
Identifier Residue Sequence Organism Cell Line
SIGNOR-261763 Asp616 EISEVKMdAEFRHDS Homo sapiens
pmid sentence
Figure 6 Preferred BACE1 and BACE2 cleavage sites. (A) Sequence of APP indicating α- and β-cleavage sites, BACE1- and BACE2-cleavage sites, and the location of mutations analyzed here. APP numbering is that of the 770-aa isoform.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255480
pmid sentence
Beta-secretase 1 (BACE1) cleaves the type-I transmembrane protein APP to form the N-terminus of Aβ.
Publications: 2 Organism: Homo Sapiens,
+ USP8up-regulates quantity by stabilization img/direct-activation.png deubiquitination BACE1 0.452
Identifier Residue Sequence Organism Cell Line
SIGNOR-259101 Lys501 ADDISLLk Homo sapiens H4 Neuroglioma Cell
pmid sentence
Accordingly, we reported that BACE1 is ubiquitinated at lysine 501 and that lack of ubiquitination at lysine 501 produces BACE1 stabilization.Our findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.
Publications: 1 Organism: Homo Sapiens
+ CSNK1D img/unknown.png phosphorylation BACE1 0.368
Identifier Residue Sequence Organism Cell Line
SIGNOR-250797 Ser498 DDFADDIsLLK Homo sapiens HEK-293 Cell
pmid sentence
Here, we report that BACE can be phosphorylated within its cytoplasmic domain at serine residue 498 by casein kinase 1. Phosphorylation exclusively occurs after full maturation of BACE by propeptide cleavage and complex N-glycosylation. | After reinternalization, BACE wild type as well as BACE S498D are efficiently retrieved from early endosomal compartments and further targeted to later endosomal compartments and/or the trans-Golgi network. In contrast, nonphosphorylatable BACE S498A is retained within early endosomes.
Publications: 1 Organism: Homo Sapiens
+ CDK5/CDK5R1up-regulates activity img/direct-activation.png phosphorylation BACE1 0.377
Identifier Residue Sequence Organism Cell Line
SIGNOR-276934 Thr252 YTGSLWYtPIRREWY Rattus norvegicus PC-12 Cell
pmid sentence
First, we show that BACE1 is phosphorylated by the p25/Cdk5 complex at Thr252 and that this phosphorylation increases BACE1 activity. 
Publications: 1 Organism: Rattus Norvegicus
+ CDK5up-regulates activity img/direct-activation.png phosphorylation BACE1 0.444
Identifier Residue Sequence Organism Cell Line
SIGNOR-278249 Thr252 YTGSLWYtPIRREWY Homo sapiens
pmid sentence
BACE1 is phosphorylated by p25 and Cdk5 at Thr252.|Our finding that p25/Cdk5 stimulates BACE1 activity supports that p25/Cdk5 may represent a promising target for the development of drugs to treat Alzheimer's disease.
Publications: 1 Organism: Homo Sapiens
+ STUB1down-regulates quantity img/direct_inhibition.png ubiquitination BACE1 0.38
Identifier Residue Sequence Organism Cell Line
SIGNOR-278719 Homo sapiens
pmid sentence
This result establishes that CHIP negatively regulates BACE1 stability.|Thus, both deletion mutants of CHIP could not enhance the ubiquitination of BACE1, suggesting that both domains of CHIP were essential for ubiquitination and degradation of BACE1.
Publications: 1 Organism: Homo Sapiens
+ FBXO2down-regulates quantity by destabilization img/direct_inhibition.png binding BACE1 0.526
Identifier Residue Sequence Organism Cell Line
SIGNOR-271904 Mus musculus Neuron
pmid sentence
SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function. We report that the SCF(Fbx2) -E3 ligase is involved in the binding and ubiquitination of BACE1 via its Trp 280 residue of F-box-associated domain. we found that overexpression of Fbx2 in the primary cortical and hippocampal neurons derived from Tg2576 transgenic mice significantly promoted BACE1 degradation and reduced β-amyloid production.
Publications: 1 Organism: Mus Musculus
+ USP8up-regulates quantity img/direct-activation.png deubiquitination BACE1 0.452
Identifier Residue Sequence Organism Cell Line
SIGNOR-266905 Homo sapiens H4 Neuroglioma Cell
pmid sentence
Here, we report that RNAi-mediated depletion of USP8 reduced levels of both ectopically expressed and endogenous BACE1 in H4 human neuroglioma cells. Moreover, USP8 depletion increased BACE1 ubiquitination, promoted BACE1 accumulation in the early endosomes and late endosomes/lysosomes, and decreased levels of BACE1 in the recycling endosomes.
Publications: 1 Organism: Homo Sapiens
+ Cullin 1-RBX1-Skp1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination BACE1 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-271903 Mus musculus Neuron
pmid sentence
SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function. We report that the SCF(Fbx2) -E3 ligase is involved in the binding and ubiquitination of BACE1 via its Trp 280 residue of F-box-associated domain. we found that overexpression of Fbx2 in the primary cortical and hippocampal neurons derived from Tg2576 transgenic mice significantly promoted BACE1 degradation and reduced β-amyloid production.
Publications: 1 Organism: Mus Musculus
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