Summary

Name MLF1
Full Name Myeloid leukemia factor 1
Synonyms Myelodysplasia-myeloid leukemia factor 1
Primary ID P58340
Links - -
Type protein
Relations 3
Function Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png unknown TP53 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding COPS3 0.87
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown RFWD2 0.82
Publications: 1 Organism: Homo Sapiens