Summary

Name DAB2
Full Name Disabled homolog 2
Synonyms Adaptor molecule disabled-2, Differentially expressed in ovarian carcinoma 2, DOC-2, Differentially-expressed protein 2 | DOC2
Primary ID P98082
Links - -
Type protein
Relations 9
Function Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation DAB2 0.3
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DAB2 0.303
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation DAB2 0.3
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation DAB2 0.301
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DAB2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DAB2 0.486
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding LRP6 0.512
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DAB2IP 0.542
Publications: 1 Organism: Homo Sapiens