| + |
HDLBP | up-regulates activity 
binding
|
RAD51 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266697 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 33941620 |
We show that vigilin interacts with the DNA damage response (DDR) proteins RAD51 and BRCA1, and vigilin depletion impairs their recruitment to DSB sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDLBP | up-regulates 
|
HDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266692 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9925647 |
HBP/vigilin binds HDL and apoA-I on ligand blots; conceivably therefore apoA-I may interact with cytoplasmic vigilin promoting changes in cholesterol flux. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDLBP | up-regulates activity
binding
|
CTCF |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266693 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 24725430 |
Vigilin interacts with CCCTC-binding factor (CTCF) and is involved in CTCF-dependent regulation of the imprinted genes Igf2 and H19. vigilin is present at several known CTCF target sites, such as the promoter regions of c-myc and BRCA1, the locus control region of β-globin, and several regions within the Igf2/H19 locus. These results reveal the functional relevance of vigilin and CTCF, and show that the CTCF-vigilin complex contributes to regulation of Igf2/H19. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDLBP | down-regulates quantity by repression 
transcriptional regulation
|
CSF1R |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266696 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 33941620 |
Vigilin (Vgl1) is essential for heterochromatin formation, chromosome segregation, and mRNA stability and is associated with autism spectrum disorders and cancer: vigilin, for example, can suppress proto-oncogene c-fms expression in breast cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDLBP | up-regulates activity
binding
|
BRCA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266698 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 33941620 |
We show that vigilin interacts with the DNA damage response (DDR) proteins RAD51 and BRCA1, and vigilin depletion impairs their recruitment to DSB sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDLBP | up-regulates
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266695 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33941620 |
Vigilin (Vgl1) is essential for heterochromatin formation, chromosome segregation, and mRNA stability and is associated with autism spectrum disorders and cancer: vigilin, for example, can suppress proto-oncogene c-fms expression in breast cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDLBP | up-regulates
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266694 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33941620 |
Vigilin (Vgl1) is essential for heterochromatin formation, chromosome segregation, and mRNA stability and is associated with autism spectrum disorders and cancer: vigilin, for example, can suppress proto-oncogene c-fms expression in breast cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HDLBP
- 
- 