| + |
SCN7A | form complex 
binding
|
Nax cation channel complex SCN2B-SCN3B variant |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280801 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22992729 |
Voltage-gated Na(+) channels in the brain are composed of a single pore-forming α subunit, one non-covalently linked β subunit (β1 or β3), and one disulfide-linked β subunit (β2 or β4). The final step in Na(+) channel biosynthesis in central neurons is concomitant α-β2 disulfide linkage and insertion into the plasma membrane. Consistent with this, Scn2b (encoding β2) null mice have reduced Na(+) channel cell surface expression in neurons, and action potential conduction is compromised. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN7A | form complex
binding
|
Nax cation channel complex, SCN3B-SCN4B variant |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280803 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22992729 |
Voltage-gated Na(+) channels in the brain are composed of a single pore-forming α subunit, one non-covalently linked β subunit (β1 or β3), and one disulfide-linked β subunit (β2 or β4). The final step in Na(+) channel biosynthesis in central neurons is concomitant α-β2 disulfide linkage and insertion into the plasma membrane. Consistent with this, Scn2b (encoding β2) null mice have reduced Na(+) channel cell surface expression in neurons, and action potential conduction is compromised. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN7A | form complex
binding
|
Nax cation channel complex, SCN1B-SCN4B variant |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280806 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22992729 |
Voltage-gated Na(+) channels in the brain are composed of a single pore-forming α subunit, one non-covalently linked β subunit (β1 or β3), and one disulfide-linked β subunit (β2 or β4). The final step in Na(+) channel biosynthesis in central neurons is concomitant α-β2 disulfide linkage and insertion into the plasma membrane. Consistent with this, Scn2b (encoding β2) null mice have reduced Na(+) channel cell surface expression in neurons, and action potential conduction is compromised. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN7A | form complex
binding
|
Nax cation channel complex, SCN1B-SCN2B variant |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280810 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22992729 |
Voltage-gated Na(+) channels in the brain are composed of a single pore-forming α subunit, one non-covalently linked β subunit (β1 or β3), and one disulfide-linked β subunit (β2 or β4). The final step in Na(+) channel biosynthesis in central neurons is concomitant α-β2 disulfide linkage and insertion into the plasma membrane. Consistent with this, Scn2b (encoding β2) null mice have reduced Na(+) channel cell surface expression in neurons, and action potential conduction is compromised. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SCN7A
- 
- 