Summary

Name XPC
Full Name DNA repair protein complementing XP-C cells
Synonyms Xeroderma pigmentosum group C-complementing protein, p125 | XPCC
Primary ID Q01831
Links - -
Type protein
Relations 1
Function Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:19609301, PubMed:20649465, PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function

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Relations

Regulator Mechanism target score ℹ
+ ATRup-regulates img/direct-activation.png binding XPC 0.494
Publications: 1 Organism: Homo Sapiens