Summary

Name ATR
Full Name Serine/threonine-protein kinase ATR
Synonyms Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1 | FRP1
Primary ID Q13535
Links - -
Type protein
Relations 56
Pathways DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
Function Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CREB1 0.358
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ img/unknown.png phosphorylation MCM2 0.691
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BRCA1 0.792
Publications: 6 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ up-regulates activity img/direct-activation.png phosphorylation MCC 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FANCA 0.579
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.729
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates activity img/direct-activation.png phosphorylation XPA 0.506
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation XPA 0.506
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATM 0.74
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates activity img/direct-activation.png phosphorylation XRCC3 0.473
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation E2F1 0.388
Publications: 1 Organism: Mus Musculus
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation CHEK1 0.921
Publications: 2 Organism: Homo Sapiens
Pathways:DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G2/M phase transition
+ img/unknown.png phosphorylation RPA2 0.742
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NBN 0.774
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MDM2 0.493
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates img/direct_inhibition.png phosphorylation DBF4 0.633
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KMT2A 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation POLH 0.424
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ up-regulates activity img/direct-activation.png phosphorylation RAD17 0.85
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SMARCAL1 0.513
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATRIP 0.874
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FANCD2 0.655
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZDHHC13 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation PRKDC 0.311
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates activity img/direct-activation.png phosphorylation CCAR2 0.409
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CHEK2 0.849
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates activity img/direct-activation.png phosphorylation WDHD1 0.552
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RBBP8 0.587
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATR 0.582
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation USP20 0.314
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATR 0.802
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.792
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ up-regulates img/indirect-activation.png ATR 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates img/direct-activation.png binding XPC 0.489
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATR 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation MCM4 0.706
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATR 0.634
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PI4K2A 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CDS1 0.353
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCM6 0.537
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ATR 0.25
Publications: 1 Organism: Homo Sapiens