| + |
trimipramine | down-regulates activity 
chemical inhibition
|
SLC6A3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258740 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9537821 |
At the human dopamine transporter, sertraline and nomifensine were the most potent with KD's of 25±2 and 56±3, respectively. Except for these two compounds, most antidepressants were not potent at the human dopamine transporter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Phenelzine | down-regulates activity
chemical inhibition
|
SLC6A3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258745 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9537821 |
At the human dopamine transporter, sertraline and nomifensine were the most potent with KD's of 25±2 and 56±3, respectively. Except for these two compounds, most antidepressants were not potent at the human dopamine transporter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
atomoxetine | down-regulates activity
chemical inhibition
|
SLC6A3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259070 |
|
|
in vitro |
|
| pmid |
sentence |
| 9871604 |
The gamma-amino alcohol/ether unit contained in venlafaxine, 2 fluoxetine, 3 and tomoxetine 3 has been prepared by a sequence of nitrile aldol reaction and nitrile reduction. Equilibrium dissociation constants KD for binding of (_+)-2 and (_+)-3 to hSERT, hNET, and hDAT are given in Table 2. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SLC6A3 | up-regulates quantity 
relocalization
|
dopamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269196 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30465801 |
Key regulators of transmitter release and the signaling dynamics of dopamine are the plasma membrane reuptake transporter (DAT) and the vesicular monoamine transporter (VMAT2). These proteins serve to remove dopamine molecules from the extracellular and cytosolic space, respectively and both determine the amount of transmitter released from synaptic vesicles. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269189 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30465801 |
Key regulators of transmitter release and the signaling dynamics of dopamine are the plasma membrane reuptake transporter (DAT) and the vesicular monoamine transporter (VMAT2). These proteins serve to remove dopamine molecules from the extracellular and cytosolic space, respectively and both determine the amount of transmitter released from synaptic vesicles. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
levomilnacipran | down-regulates activity
chemical inhibition
|
SLC6A3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257944 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18468895 |
Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
clomipramine | down-regulates activity
chemical inhibition
|
SLC6A3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258875 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9537821 |
At the human dopamine transporter, sertraline and nomifensine were the most potent with KD's of 25±2 and 56±3, respectively. Except for these two compounds, most antidepressants were not potent at the human dopamine transporter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
QOCYWLABLBUJOR-UHFFFAOYSA-N | down-regulates activity
chemical inhibition
|
SLC6A3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257796 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18487050 |
For [3H]paroxetine, [3H]citalopram, [3H]nisoxetine, and [3H]WIN35,428 the following KD values were obtained on the human monoamine transporters hSERT, hNET, and hDAT by homologous competition experiments: 0.69 nM [3H]paroxetine, 4.46 nM [3H]citalopram, 6.77 nM [3H]nisoxetine, and 24.1 [3H]WIN35,428. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SLC6A3
- 
- 