| + |
CREB5 | up-regulates quantity by expression 
transcriptional regulation
|
TGFBR3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253811 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21132541 |
Our result verified CREB5 biological regulation module in the upstream of frontal cortex of HIVE-control patients (MAPKAPK3 activation; DGKG, LY96, TNFRSF11B inhibition) and downstream (ATP6V0E1, CFB, DGKG, MX1, TGFBR3 activation; LGALS3BP, RASGRP3, RDX, STAT1 inhibition), |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HCE-7 Cell |
| + |
TGFB2 | up-regulates 
binding
|
TGFBR3 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-76473 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10746731 |
Betaglycan binds tgf-b isoforms with high affinity and increases the functional interaction between tgf-b and its type ii and type i signalling receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INHA | down-regulates 
binding
|
TGFBR3 |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-76470 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10746731 |
Type iii tgf-beta receptor, betaglycan, can function as an inhibin co-receptor with actrii. Betaglycan binds inhibin with high affinity and enhances binding in cells co-expressing actrii and betaglycan. ability of betaglycan to facilitate inhibin antagonism of activin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
miR-501-3p | down-regulates quantity by repression
post transcriptional regulation
|
TGFBR3 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282643 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 31307515 |
M2 macrophage-derived exosomal miR-501-3p inhibits tumor suppressor TGFBR3 gene and facilitates the development of PDAC by activating the TGF-β signaling pathway, which provides novel targets for the molecular treatment of PDAC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFBR3 | up-regulates activity
binding
|
BMP2 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282644 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18184661 |
The TGF-beta type III receptor (TbetaRIII or betaglycan) is an abundant cell surface proteoglycan that has been well characterized as a TGF-beta and inhibin receptor. Here we demonstrate that TbetaRIII functions as a BMP cell surface receptor. TbetaRIII directly and specifically binds to multiple members of the BMP subfamily, including BMP-2, BMP-4, BMP-7, and GDF-5, with similar kinetics and ligand binding domains as previously identified for TGF-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFBR3 | up-regulates activity
binding
|
BMP4 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282645 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18184661 |
The TGF-beta type III receptor (TbetaRIII or betaglycan) is an abundant cell surface proteoglycan that has been well characterized as a TGF-beta and inhibin receptor. Here we demonstrate that TbetaRIII functions as a BMP cell surface receptor. TbetaRIII directly and specifically binds to multiple members of the BMP subfamily, including BMP-2, BMP-4, BMP-7, and GDF-5, with similar kinetics and ligand binding domains as previously identified for TGF-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFBR3 | up-regulates activity
binding
|
BMP7 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282646 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18184661 |
The TGF-beta type III receptor (TbetaRIII or betaglycan) is an abundant cell surface proteoglycan that has been well characterized as a TGF-beta and inhibin receptor. Here we demonstrate that TbetaRIII functions as a BMP cell surface receptor. TbetaRIII directly and specifically binds to multiple members of the BMP subfamily, including BMP-2, BMP-4, BMP-7, and GDF-5, with similar kinetics and ligand binding domains as previously identified for TGF-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFBR3 | up-regulates activity
binding
|
GDF5 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282647 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18184661 |
The TGF-beta type III receptor (TbetaRIII or betaglycan) is an abundant cell surface proteoglycan that has been well characterized as a TGF-beta and inhibin receptor. Here we demonstrate that TbetaRIII functions as a BMP cell surface receptor. TbetaRIII directly and specifically binds to multiple members of the BMP subfamily, including BMP-2, BMP-4, BMP-7, and GDF-5, with similar kinetics and ligand binding domains as previously identified for TGF-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
TGFBR3
- 
- 