| + |
PRKCA | down-regulates activity 
phosphorylation
|
GFPT1 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249040 |
Ser205 |
AVGTRRGsPLLIGVR |
in vitro |
|
| pmid |
sentence |
| 10806197 |
Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRKAA1 | down-regulates
phosphorylation
|
GFPT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183528 |
Ser242 |
SKFTRWGsQGERGKD |
Homo sapiens |
|
| pmid |
sentence |
| 19170765 |
Amp-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at ser243 to modulate its enzymatic activityhe 2-dg induced phosphorylation of gfat1 . The assay of the gfat enzymatic activity in the cell lysates indicated that the 2-dg-treatment inhibited the enzymatic activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | up-regulates 
phosphorylation
|
GFPT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158490 |
Ser261 |
CNLSRVDsTTCLFPV |
Homo sapiens |
|
| pmid |
sentence |
| 17941647 |
Amp-activated protein kinase and calcium/calmodulin-dependent kinase ii were identified to phosphorylate specifically ser243 in vitro. Phosphorylation by these two kinases results in an increase of enzymatic activity by 1.4-fold. These findings suggest for the first time that hgfat1 may be regulated by kinases other than pka. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK2A | up-regulates
phosphorylation
|
GFPT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158486 |
Ser261 |
CNLSRVDsTTCLFPV |
Homo sapiens |
|
| pmid |
sentence |
| 17941647 |
Amp-activated protein kinase and calcium/calmodulin-dependent kinase ii were identified to phosphorylate specifically ser243 in vitro. Phosphorylation by these two kinases results in an increase of enzymatic activity by 1.4-fold. These findings suggest for the first time that hgfat1 may be regulated by kinases other than pka. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GFPT1 | up-regulates 
|
Hexosamine_biosynthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267819 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21310273 |
GFPT1 is the key enzyme of the hexosamine pathway yielding the amino sugar UDP-N-acetylglucosamine, an essential substrate for protein glycosylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GFPT1 | down-regulates quantity
chemical modification
|
L-glutamine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267816 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21310273 |
GFPT1 catalyzes the transfer of an amino group from glutamine onto fructose-6-phosphate, yielding glucosamine-6-phosphate (GlcN-6-P) and glutamate. This transamidase reaction has been identified as the first and rate-limiting step of the hexosamine biosynthesis pathway, which is the obligatory source of essential amino sugars for the synthesis of glycoproteins, glycolipids, and proteoglycans |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamine metabolism |
| + |
GFPT1 | up-regulates quantity
chemical modification
|
L-glutamate(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267818 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21310273 |
GFPT1 catalyzes the transfer of an amino group from glutamine onto fructose-6-phosphate, yielding glucosamine-6-phosphate (GlcN-6-P) and glutamate. This transamidase reaction has been identified as the first and rate-limiting step of the hexosamine biosynthesis pathway, which is the obligatory source of essential amino sugars for the synthesis of glycoproteins, glycolipids, and proteoglycans |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamine metabolism |
| + |
GFPT1 | down-regulates quantity
chemical modification
|
D-fructofuranose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267815 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21310273 |
GFPT1 catalyzes the transfer of an amino group from glutamine onto fructose-6-phosphate, yielding glucosamine-6-phosphate (GlcN-6-P) and glutamate. This transamidase reaction has been identified as the first and rate-limiting step of the hexosamine biosynthesis pathway, which is the obligatory source of essential amino sugars for the synthesis of glycoproteins, glycolipids, and proteoglycans |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GFPT1 | up-regulates
|
Protein_glycosylation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267820 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21310273 |
GFPT1 is the key enzyme of the hexosamine pathway yielding the amino sugar UDP-N-acetylglucosamine, an essential substrate for protein glycosylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GFPT1 | up-regulates quantity
chemical modification
|
2-ammonio-2-deoxy-D-glucopyranose 6-phosphate(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267817 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21310273 |
GFPT1 catalyzes the transfer of an amino group from glutamine onto fructose-6-phosphate, yielding glucosamine-6-phosphate (GlcN-6-P) and glutamate. This transamidase reaction has been identified as the first and rate-limiting step of the hexosamine biosynthesis pathway, which is the obligatory source of essential amino sugars for the synthesis of glycoproteins, glycolipids, and proteoglycans |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GFPT1
- 
- 