Summary

Name CAMK2A
Full Name Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms CaM kinase II subunit alpha, CaMK-II subunit alpha | CAMKA, KIAA0968
Primary ID Q9UQM7
Links - -
Type protein
Relations 71
Function CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SRF 0.23
Publications: 2
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.03
Publications: 7 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.13
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PEA15 0.23
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GFAP 0.15
Publications: 4 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.78
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CREB1 0.17
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation LRRC7 0.71
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation RCHY1 0.26
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.25
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TH 0.05
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation CACNA1B
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HSF1 0.22
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation DLG1 0.50
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation RIMS1 0.56
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation NCOR2 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ETS2 0.18
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ETS1 0.21
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GFPT1 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation OPRM1 0.06
Publications: 3 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png phosphorylation CAMK2A
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ATP2A2 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HRH1 0.15
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
+ img/unknown.png phosphorylation KRT18 0.28
Publications: 1
+ img/unknown.png phosphorylation PDC 0.31
Publications: 2
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT 0.19
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.43
Publications: 2 Organism: Homo Sapiens
Tissue: Smooth Muscle
+ up-regulates activity img/direct-activation.png phosphorylation CD44 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CD44 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS1 0.14
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation LIPE 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GABBR1 0.11
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png dephosphorylation CAMK2A 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAMK2A
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation ITPKA 0.30
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary, Brain
+ up-regulates activity img/direct-activation.png phosphorylation ITGB1BP1 0.28
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation CHAT 0.21
Publications: 1 Organism: Homo Sapiens
Tissue: Brain