Summary

Name TLE5
Full Name TLE family member 5
Synonyms Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG | GRG, GRG5
Primary ID Q08117
Links - -
Type protein
Relations 4
Function Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding SIX3 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding SIX6 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding TLE5 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ZNF503 0.2
Publications: 1 Organism: Chlorocebus Aethiops