Summary

Name DDR1
Full Name Epithelial discoidin domain-containing receptor 1
Synonyms Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, MCK-10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, Tyrosine kinase DDR, Tyrosine-protein kinase CAK | CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
Primary ID Q08345
Links - -
Type protein
Relations 6
Function Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ DDR1up-regulates activity img/direct-activation.png phosphorylation DDR1 0.2
Publications: 1 Organism: Homo Sapiens
+ COL21A1up-regulates activity img/direct-activation.png binding DDR1 0.2
Publications: 1 Organism: Homo Sapiens
+ COL1A1up-regulates img/direct-activation.png binding DDR1 0.346
Publications: 1 Organism: Homo Sapiens
+ COL1A1up-regulates activity img/direct-activation.png binding DDR1 0.346
Publications: 1 Organism: Homo Sapiens
+ DDR1up-regulates activity img/direct-activation.png relocalization PTPN11 0.382
Publications: 1 Organism: Canis Lupus Familiaris
+ DDR1up-regulates activity img/direct-activation.png binding TM4SF1 0.441
Publications: 1