Summary

Name AIMP1
Full Name Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
Synonyms Multisynthase complex auxiliary component p43 | EMAP2, SCYE1
Primary ID Q12904
Links - -
Type protein
Relations 4
Function Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation AIMP1 0.484
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Multiaminoacyl-tRNA synthetase 0.917
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMURF2 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMURF2 0.399
Publications: 1 Organism: Homo Sapiens