Summary

Name EPS8
Full Name Epidermal growth factor receptor kinase substrate 8
Synonyms EPS8_HUMAN |
Primary ID Q12929
Links - -
Type protein
Relations 4
Function Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation EPS8 0.329
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation EPS8 0.361
Publications: 3 Organism: Homo Sapiens