Summary

Name MAPK3
Full Name Mitogen-activated protein kinase 3
Synonyms MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1 | ERK1, PRKM3
Primary ID P27361
Links - -
Type protein
Relations 398
Pathways Glucocorticoid receptor Signaling
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation JUND 0.474
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HDAC6 0.438
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.691
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LIFR 0.307
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POU5F1 0.354
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PPARG 0.413
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SOS1 0.62
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SREBF1 0.457
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.273
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.58
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TAL1 0.364
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIC 0.386
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation THRB 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.697
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.306
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.625
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TOB1 0.364
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BAZ1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DUSP6 0.847
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POLR2A 0.322
Publications: 23 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTTG1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RCAN1 0.389
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.511
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation PCBP2 0.329
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAGEA11 0.303
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation APBB1 0.273
Publications: 4 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MITF 0.521
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation PAX5 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CEBPA 0.384
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MCRIP1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ETV6 0.325
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.713
Publications: 8 Organism: Chlorocebus Aethiops, Mus Musculus, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NUP50 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.7
Publications: 8 Organism: Chlorocebus Aethiops, Mus Musculus, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ABI1 0.427
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SPHK1 0.59
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.52
Publications: 1 Organism: In Vitro
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.713
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.739
Publications: 15 Organism: Homo Sapiens
Tissue: Lung, Lung, Breast
+ down-regulates activity img/direct_inhibition.png phosphorylation STMN1 0.56
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.625
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.496
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT (isoform 2) 0.482
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation HSPB8 0.346
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HSPB8 0.346
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation ALOX5 0.338
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.348
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.272
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPK 0.352
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HNRNPK 0.352
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.348
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.618
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation TFCP2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AMPH 0.278
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.583
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RUNX2 0.546
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PGR 0.541
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.583
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AMPH 0.278
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation DUSP1 0.777
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.618
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSF1 0.612
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PCYT1A 0.434
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ down-regulates activity img/direct_inhibition.png phosphorylation NUP50 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IRX2 0.2
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.577
Publications: 6 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL6 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP2R5C 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.435
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DUSP1 0.777
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.563
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.707
Publications: 6 Organism: , Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ASB2 0.268
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.563
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.615
Publications: 6 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation SPHK2 0.504
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.704
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.436
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARRB1 0.703
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation XPO5 0.318
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB10 0.306
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation METTL3 0.274
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KRT8 0.43
Publications: 2 Organism: Homo Sapiens,
+ up-regulates img/direct-activation.png phosphorylation SREBF2 0.402
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.586
Publications: 3 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Carcinoma Cell
+ down-regulates img/direct_inhibition.png phosphorylation MRTFA 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KLC1 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SYN3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAPN2 0.544
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLA2G4A 0.642
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation JAK2 0.499
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NUP153 0.401
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PML 0.346
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYB 0.308
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.681
Publications: 3 Organism: Mus Musculus, Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.273
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation SP1 0.636
Publications: 6 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates activity img/direct-activation.png phosphorylation LCK 0.543
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.695
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MYC 0.695
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation STMN2 0.359
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation TH 0.498
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GAB2 0.6
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EPS8 0.331
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation JUN 0.774
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation RRN3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.688
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GTF2I 0.383
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GRK2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NFATC4 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1 0.338
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ARHGAP26 0.2
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.721
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPTOR 0.486
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.536
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PDE4D 0.256
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.709
Publications: 4 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.709
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SP3 0.305
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS2 0.366
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.458
Publications: 3 Organism: Homo Sapiens
Tissue: Smooth Muscle, Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.328
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5A 0.693
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation IL16 0.271
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.299
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTPN7 0.676
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLCB1 0.423
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MED1 0.268
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SULT4A1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation UBTF 0.556
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.455
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LAT 0.312
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.694
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.777
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.737
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.2
Publications: 3 Organism: , Homo Sapiens
Tissue: Heart
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.726
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.629
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Heart
+ up-regulates img/direct-activation.png phosphorylation FOS 0.707
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MBP 0.519
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.652
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TRPV3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD4 0.435
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.345
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.381
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTPRR 0.652
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation ETS1 0.656
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MKNK1 0.551
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS3 0.362
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS3 0.362
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.299
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SP1 0.636
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAD 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.536
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SPIB 0.316
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1B 0.282
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1G 0.285
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.725
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.536
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAZ 0.305
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ADAM17 0.374
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.625
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EWSR1 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.739
Publications: 3 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates activity img/direct-activation.png phosphorylation LIPE 0.427
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.647
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.543
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.472
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.444
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK3 0.587
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MAPK3 0.52
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid receptor Signaling
+ down-regulates img/direct_inhibition.png binding MAPK3 0.687
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.777
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD1 0.504
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation E2F1 0.299
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.737
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.75
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.607
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.847
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK3 0.614
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.457
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MKNK1 0.551
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation mTORC1 0.397
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.472
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA2 0.701
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.322
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation MAPK3 0.444
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png BRD4 0.318
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.487
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.726
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.561
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation SOX9 0.394
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK3 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYL1 0.293
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.739
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK3 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization PPARG 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation MKNK2 0.491
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation mTORC1 0.397
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX9 0.394
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation THR 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MAPK3 0.754
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCKIPSD 0.435
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation mTORC1 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.407
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK3 0.585
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK3 0.481
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.457
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B/Axin/APC 0.357
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png MAPK3 0.589
Publications: 1 Organism: Homo Sapiens