Summary

Name MAPK3
Full Name Mitogen-activated protein kinase 3
Synonyms MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1 | ERK1, PRKM3
Primary ID P27361
Links - -
Type protein
Relations 371
Pathways Glucocorticoid Receptor
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation JUND 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HDAC6 0.17
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.11
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LIFR 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POU5F1 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation, relocalization PPARG 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SOS1 0.22
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SREBF1 0.20
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.15
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.07
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TAL1 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TAL1 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIC
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation THRB 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation THRB 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.06
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.18
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TOB1 0.15
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BAZ1B 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DUSP6 0.33
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POLR2A 0.35
Publications: 23 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTTG1 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RCAN1 0.10
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAGEA11 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation APBB1
Publications: 4 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MITF
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation KARS 0.24
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CEBPA 0.10
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ETV6
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NUP50 0.32
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.47
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens, Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation RPS6K
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens, Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ABI1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SPHK1 0.17
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.15
Publications: 3 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.40
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.30
Publications: 15 Organism: Homo Sapiens
Tissue: Lung, Lung, Breast
+ down-regulates activity img/direct_inhibition.png phosphorylation STMN1 0.35
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.16
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RXRA 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HSPB8 0.17
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HSPB8 0.17
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPK 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HNRNPK 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.54
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H3F3A 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TFCP2 0.12
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AMPH 0.09
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.15
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PGR 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RUNX2 0.12
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DUSP1 0.36
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.54
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSF1 0.37
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PCYT1A
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.35
Publications: 6 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL6 0.11
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP2R5C 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DUSP1 0.36
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.30
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOS 0.32
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.30
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.21
Publications: 6 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.15
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation SPHK2 0.12
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.33
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARRB1 0.29
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB10 0.18
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation LCK 0.30
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.13
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KRT8 0.31
Publications: 2 Organism: Homo Sapiens,
+ up-regulates img/direct-activation.png phosphorylation SREBF2 0.17
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.21
Publications: 3 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Carcinoma Cell
+ down-regulates img/direct_inhibition.png phosphorylation MKL1 0.24
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KLC1 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SYN3 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAPN2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLA2G4A 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation JAK2 0.15
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NUP153
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PML 0.24
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYB 0.07
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.31
Publications: 3 Organism: Mus Musculus, Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png phosphorylation LCK 0.30
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates img/direct-activation.png phosphorylation SP1 0.15
Publications: 6 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IRS1 0.21
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation STMN2 0.22
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation TH 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GAB2 0.18
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUN 0.33
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates img/direct-activation.png phosphorylation RRN3 0.21
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.15
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GTF2I 0.34
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GRK2 0.18
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NFATC4 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1 0.07
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL2L11 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPTOR 0.32
Publications: 5 Organism: Homo Sapiens, Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.06
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PDE4D 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3
Publications: 4 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation SP3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS2 0.04
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.27
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5A 0.29
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation IL16 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN7 0.21
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLCB1 0.16
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MED1 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SULT4A1
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation UBTF 0.30
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LAT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3
Publications: 3 Organism: , Homo Sapiens
Tissue: Heart
Pathways:Glucocorticoid Receptor
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.79
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.82
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK3
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3
Publications: 2 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3
Publications: 1 Organism: Homo Sapiens
Tissue: Heart
+ down-regulates img/direct_inhibition.png phosphorylation MBP 0.22
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD4 0.20
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.29
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.17
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTPRR 0.17
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation ETS1 0.20
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MKNK1 0.19
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS3 0.37
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS3 0.37
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SP1 0.15
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAD 0.32
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SPIB 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1B 0.04
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1G 0.04
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.31
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAZ 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ADAM17 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL2 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.27
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EWSR1 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2
Publications: 3 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates activity img/direct-activation.png phosphorylation LIPE 0.10
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.22
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.30
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAPK3 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCKIPSD 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.23
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates img/direct-activation.png phosphorylation mTORC1
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYL1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown MAPK3
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png phosphorylation SMAD1 0.17
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates img/indirect-activation.png unknown MAPK3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.30
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates img/direct-activation.png binding MAPK3 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX9 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown MAPK3 0.39
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK3 0.21
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAPK3 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation MAPK3 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation E2F1
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK3 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.12
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation mTORC1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MKNK2 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA2 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown MAPK3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MKNK1
Publications: 1 Organism: In Vitro
+ up-regulates img/indirect-activation.png transcriptional regulation SOX9 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK3 0.10
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation mTORC1
Publications: 1 Organism: Homo Sapiens