| + |
MAPK9 | down-regulates 
phosphorylation, relocalization
|
NFATC3 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53364 |
Ser163 |
SYRESSLsPSPASSI |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9374467 |
Ser163 and ser165 represent the major sites of in vitro phosphorylation of nfat4 by jnk. / the negative regulation of nfat4 nuclear accumulation caused by jnk provides a mechanism for cell type?specific Responses to extracellular stimulation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53368 |
Ser165 |
RESSLSPsPASSISS |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9374467 |
Ser163 and ser165 represent the major sites of in vitro phosphorylation of nfat4 by jnk. / the negative regulation of nfat4 nuclear accumulation caused by jnk provides a mechanism for cell type?specific Responses to extracellular stimulation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103360 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14517246 |
Jnks directly phosphorylate nuclear factor of activated t-cell (nfat) transcription factors, thus antagonizing the effects of calcium-regulated signaling through the protein phosphatase calcineurin. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1 | down-regulates activity
phosphorylation
|
NFATC3 |
0.572 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109800 |
Ser207 |
AARFTLGsPLTSPGG |
Homo sapiens |
BHK Cell |
| pmid |
sentence |
| 9630228 |
Dominant-negative cki? Induces nuclear import of nf-at4these results demonstrated that the cki? Phosphorylation sites identified in vitro were also specifically phosphorylated by cki? In vivo, and that these residues were crucial for the masking of the nls of nf-at4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109763 |
Ser211 |
TLGSPLTsPGGSPGG |
Homo sapiens |
BHK Cell |
| pmid |
sentence |
| 9630228 |
Dominant-negative cki alpha Induces nuclear import of nf-at4 these results demonstrated that the cki alpha Phosphorylation sites identified in vitro were also specifically phosphorylated by cki alpha In vivo, and that these residues were crucial for the masking of the nls of nf-at4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109781 |
Ser215 |
PLTSPGGsPGGCPGE |
Homo sapiens |
BHK Cell |
| pmid |
sentence |
| 9630228 |
Dominant-negative cki alpha Induces nuclear import of nf-at4 these results demonstrated that the cki alpha Phosphorylation sites identified in vitro were also specifically phosphorylated by cki alpha In vivo, and that these residues were crucial for the masking of the nls of nf-at4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109768 |
Thr204 |
NEAAARFtLGSPLTS |
Homo sapiens |
|
| pmid |
sentence |
| 9630228 |
Dominant-negative cki alpha Induces nuclear import of nf-at4 these results demonstrated that the cki alpha Phosphorylation sites identified in vitro were also specifically phosphorylated by cki alpha In vivo, and that these residues were crucial for the masking of the nls of nf-at4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109776 |
Thr210 |
FTLGSPLtSPGGSPG |
Homo sapiens |
BHK Cell |
| pmid |
sentence |
| 9630228 |
Dominant-negative cki alpha Induces nuclear import of nf-at4 these results demonstrated that the cki alpha Phosphorylation sites identified in vitro were also specifically phosphorylated by cki alpha In vivo, and that these residues were crucial for the masking of the nls of nf-at4. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
NFATC3 | up-regulates quantity by expression 
transcriptional regulation
|
GPC6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264024 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21871017 |
NFAT transcriptionally regulates GPC6 induction in breast cancer cells and binds to three regulatory elements in the GPC6 proximal promoter. Expression of GPC6 in response to NFAT signalling promotes invasive migration, whereas GPC6 silencing with shRNA (small-hairpin RNA) potently blocks this phenotype. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CA | up-regulates
dephosphorylation
|
NFATC3 |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176376 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | down-regulates
phosphorylation
|
NFATC3 |
0.834 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118220 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14517246 |
Jnks directly phosphorylate nuclear factor of activated t-cell (nfat) transcription factors, thus antagonizing the effects of calcium-regulated signaling through the protein phosphatase calcineurin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC3 | up-regulates quantity by expression 
transcriptional regulation
|
TFF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254639 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16219765 |
Overexpression of NFAT3 enhanced both ERalpha and ERbeta transcriptional activities in a ligand-independent manner and up-regulated downstream estrogen-responsive genes including pS2 and cathepsin D. Reduction of endogenous NFAT3 with NFAT3 small interfering RNA or overexpression of NFAT3 deletion mutants that lack the ER-binding sites reduced the NFAT3 coactivation of ERalpha and ERbeta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin | up-regulates
dephosphorylation
|
NFATC3 |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252312 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC3 | up-regulates quantity by expression
transcriptional regulation
|
PTGS2 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264028 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21871017 |
NFAT induces the transcription of the COX2 (cyclo-oxygenase-2) gene incancer cells thereby enhancing invasive migration |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC3 | up-regulates quantity by expression
transcriptional regulation
|
CTSD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254640 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16219765 |
Overexpression of NFAT3 enhanced both ERalpha and ERbeta transcriptional activities in a ligand-independent manner and up-regulated downstream estrogen-responsive genes including pS2 and cathepsin D. Reduction of endogenous NFAT3 with NFAT3 small interfering RNA or overexpression of NFAT3 deletion mutants that lack the ER-binding sites reduced the NFAT3 coactivation of ERalpha and ERbeta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC3 | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251732 |
|
|
Homo sapiens |
Smooth Muscle |
| pmid |
sentence |
| 17079331 |
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway has been found to play a role in regulating growth and differentiation in several cell types. However, the functional significance of NFAT in the vasculature is largely unclear. Here we show that NFATc1, NFATc3, and NFATc4 are expressed in human myometrial arteries. |Chronic inhibition of NFAT significantly reduced IL-6 production in intact myometrial arteries and inhibited cell proliferation in vascular smooth muscle cells cultured from explants from the same arteries. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NFATC3
- 
- 