| + |
Calcineurin | up-regulates activity 
dephosphorylation
|
NFATC2 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252319 |
Ser168 |
YREPLCLsPASSGSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252318 |
Ser171 |
PLCLSPAsSGSSASF |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252316 |
Ser172 |
LCLSPASsGSSASFI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252326 |
Ser174 |
LSPASSGsSASFISD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252343 |
Ser175 |
SPASSGSsASFISDT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252325 |
Ser177 |
ASSGSSAsFISDTFS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252327 |
Ser180 |
GSSASFIsDTFSPYT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252329 |
Ser213 |
QNIPAHYsPRTSPIM |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252330 |
Ser217 |
AHYSPRTsPIMSPRT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252331 |
Ser221 |
PRTSPIMsPRTSLAE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252342 |
Ser268 |
VALPPGAsPQRSRSP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252328 |
Ser274 |
ASPQRSRsPSPQPSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252333 |
Ser276 |
PQRSRSPsPQPSSHV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252336 |
Ser280 |
RSPSPQPsSHVAPQD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252335 |
Ser326 |
PPKMWKTsPDPSPVS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255463 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Publications: |
16 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
Calcineurin | up-regulates activity
dephosphorylation
|
CACNA1H |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277872 |
Ser2137 |
RDLRRLYsVDAQGFL |
Mus musculus |
CAD Cell |
| pmid |
sentence |
| 38001892 |
we also discovered that a novel CaMKII-phosphorylated site, S2137, underwent dephosphorylation by calcineurin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Calcineurin | down-regulates 
dephosphorylation
|
FLNA |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252339 |
Ser2152 |
TRRRRAPsVANVGSH |
Homo sapiens |
|
| pmid |
sentence |
| 16442073 |
We report that a purified c-terminal recombinant region of filamin is a suitable substrate for calcineurin in vitro. Furthermore, 1 microm cyclosporin a (csa), a specific calcineurin inhibitor, reduced the dephosphorylation of the recombinant fragment in 293ft cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin | up-regulates activity
dephosphorylation
|
DNM1L |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252315 |
Ser637 |
VPVARKLsAREQRDC |
Homo sapiens |
|
| pmid |
sentence |
| 18838687 |
When mitochondrial depolarization is associated with sustained cytosolic Ca(2+) rise, it activates the cytosolic phosphatase calcineurin that normally interacts with Drp1. Calcineurin-dependent dephosphorylation of Drp1, and in particular of its conserved serine 637, regulates its translocation to mitochondria as substantiated by site directed mutagenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin |
dephosphorylation
|
PPP1R1A |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252334 |
Ser67 |
LKSTLAMsPRQRKKM |
Rattus norvegicus |
|
| pmid |
sentence |
| 11278334 |
In vitro and in vivo studies indicated that phospho-Ser-67 inhibitor-1 was dephosphorylated by protein phosphatases-2A and -2B. | However, inhibitor-1 phosphorylated at Ser-67 was a less efficient substrate for cAMP-dependent protein kinase. These results demonstrate regulation of a Cdk5-dependent phosphorylation site in inhibitor-1 and suggest a role for this site in modulating the amplitude of signal transduction events that involve cAMP-dependent protein kinase activation. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
Calcineurin | up-regulates activity
dephosphorylation
|
BAD |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252324 |
Ser75 |
EIRSRHSsYPAGTED |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10195903 |
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD|Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus enhancing BAD heterodimerization with Bcl-xL and promoting apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252332 |
Ser99 |
PFRGRSRsAPPNLWA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10195903 |
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD|Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus enhancing BAD heterodimerization with Bcl-xL and promoting apoptosis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Calcineurin |
dephosphorylation
|
DNM2 |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252317 |
Ser764 |
LQSASSHsPTPQRRP |
Rattus norvegicus |
|
| pmid |
sentence |
| 20496096 |
CaN is activated, targeting a set of proteins for dephosphorylation, including dynamin II |We have recently discovered that the ubiquitously expressed dynamin isoform, dynII, is phosphorylated at S764 specifically during mitosis (unpublished data). We now show that S764 is phosphorylated throughout mitosis and is dephosphorylated at the time of cytokinesis(dynII). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
cyclosporin A | down-regulates
chemical inhibition
|
Calcineurin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15276472 |
Calcineurin catalytic activity is inhibited by the immunosuppressive drugs cyclosporine and fk506 through complexes with immunophilin proteins. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255102 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 15829723 |
On one hand, inhibition of calcineurin with cyclosporin A (CsA) significantly reduced the growth of both the slow/type I soleus muscle and fast/type II plantaris muscle in normal, ambulatory rats |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Rattus Norvegicus |
| Tissue: |
Skeletal Muscle |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
CALM1 | up-regulates
binding
|
Calcineurin |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252337 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11796223 |
Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, T cell activation |
| + |
Calcineurin | up-regulates
dephosphorylation
|
NFATC4 |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252322 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin | up-regulates 
|
Chemorepulsion_of_axon |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268386 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15363394 |
In this study, we have identified CaMKII and CaN-PP1 as the downstream effectors of localized Ca2+ signals in mediating attractive and repulsive turning responses of growth cones, respectively. Local Ca2+ elevation activates CaMKII and CaN-PP1 for attraction and repulsion, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance, Oxytocin signaling |
| + |
Calcineurin | up-regulates
dephosphorylation
|
NFATC1 |
0.829 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252313 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 14722106 |
Once activated, calcineurin directly dephosphorylates NFAT proteins that are present in a hyperphosphorylated latent form in the cytoplasm and induces their rapid translocation into the nucleus, where in concert with nuclear partner proteins such as the AP-1 transcription factor complex, they are able to bind cooperatively to their target promoter elements and activate the transcription of specific NFAT target genes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, Focal segmental glomerulosclerosis, T cell activation |
| + |
Calcineurin | up-regulates
dephosphorylation, relocalization
|
NFATC2 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252321 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18676376 |
Calcineurin dephosphorylates members of the nuclear factor of activated T cells (NFAT)2 transcription factor family, allowing NFAT to translocate to the nucleus where it cooperates with other transcription factors to induce transcription of target genes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252311 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252338 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | B-cell activation |
| + |
tacrolimus (anhydrous) | down-regulates
chemical inhibition
|
Calcineurin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252308 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15276472 |
Calcineurin catalytic activity is inhibited by the immunosuppressive drugs cyclosporine and fk506 through complexes with immunophilin proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin | up-regulates
|
MYOD1 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15829723 |
Calcineurin can activate the transcription factors myocyte enhancer factor-2 and MyoD, which leads to the subsequent induction of myogenin and muscle differentiation (22). In addition, inhibition of calcineurin prevents the initiation of early stages of muscle differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
Calcineurin | up-regulates quantity by expression
|
IL6 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252340 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18177723 |
Interestingly, since IL-6 production by nerve-mediated skeletal muscle contraction has recently been shown to be partly dependent on the activation of the calcineurin pathway |The fact that IL-6 is produced not only by proliferating satellite cells but also by growing myofibers during hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CALM3 | up-regulates
binding
|
Calcineurin |
0.49 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266347 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11796223 |
Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RCAN1 | down-regulates activity
binding
|
Calcineurin |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252341 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12554096 |
MCIP proteins can bind to and inhibit calcineurin, a calcium/calmodulin-regulated serine/threonine protein phosphatase that is activated during cardiac hypertrophy and failure |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
calcium(2+) | up-regulates activity
chemical activation
|
Calcineurin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255462 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Except for nfat5, nfatc1c4 are activated upon a rise in intracellular ca2+, which stimulates the serine/threonine phosphatase activity of calcineurin the ca2+-calcineurin signal is the most important signal for regulating nfat activation, but the signal that leads to ca2+ influx during neural tube differentiation is still unclear. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance, B-cell activation, Focal segmental glomerulosclerosis, Oxytocin signaling, T cell activation |
| + |
Calcineurin | up-regulates
|
MEF2C |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252309 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
PPP3CA | form complex 
binding
|
Calcineurin |
0.954 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255291 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14623295 |
Calcineurin is a heterodimer consisting of a catalytic subunit with a molecular mass of about 59 kDa (calcienurin A or CNA) and a regulatory subunit with a molecular mass of 19 kDa (calcineurin B or CNB). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
PPP3R1 | form complex
binding
|
Calcineurin |
0.954 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255289 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14623295 |
Calcineurin is a heterodimer consisting of a catalytic subunit with a molecular mass of about 59 kDa (calcienurin A or CNA) and a regulatory subunit with a molecular mass of 19 kDa (calcineurin B or CNB). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CALM2 | up-regulates
binding
|
Calcineurin |
0.466 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266331 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11796223 |
Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
calcium(2+) | up-regulates
chemical activation
|
Calcineurin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252320 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
Non-canonical Wnt/Ca2+ pathway has also been implicated in multiple functions including cell adhesion and cell movements during gastrulation. In this signaling cascade, binding of Wnt to the Fzd receptor leads to the release of intracellular Ca2+, a process which is mediated through heterotrimeric G proteins, PLC (phospholipase C) and CamKII (calcium-calmodulin-dependent kinae II) as well as PKC (protein kinase C). The increased intracellular Ca2+ concentration also activates the calcineurin phosphatase, leading to activation of the transcription factor NFAT (nuclear factor of activated T cell). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance, B-cell activation, Focal segmental glomerulosclerosis, Oxytocin signaling, T cell activation |
| + |
IGF1 | up-regulates
|
Calcineurin |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252306 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10448861 |
Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Calcineurin | up-regulates
dephosphorylation
|
NFATC3 |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252312 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Calcineurin