Summary

Name ACACA
Full Name Acetyl-CoA carboxylase 1
Synonyms ACC1, ACC-alpha | ACAC, ACC1, ACCA
Primary ID Q13085
Links - -
Type protein
Relations 18
Pathways Fatty Acid Synthesis, Leptin Signaling
Function Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation ACACA 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation ACACA 0.686
Publications: 1 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation ACACA 0.31
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation ACACA 0.31
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png dephosphorylation ACACA 0.243
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ACACA 0.537
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Leptin Signaling
+ down-regulates img/direct_inhibition.png phosphorylation ACACA 0.683
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation ACACA 0.537
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ACACA 0.476
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification malonyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ down-regulates quantity img/direct_inhibition.png chemical modification acetyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates activity img/direct-activation.png binding ACACA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ down-regulates activity img/direct_inhibition.png binding ACACA 0.564
Publications: 1 Organism: In Vitro
+ down-regulates img/indirect_inhibition.png Food intake 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png binding ACACA 0.385
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ACACA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ACACA 0.453
Publications: 1 Organism: Mus Musculus
Tissue: Liver
+ down-regulates quantity by destabilization img/direct_inhibition.png binding ACACA 0.278
Publications: 1 Organism: Homo Sapiens