| + |
Food intake | up-regulates quantity 
|
vitamin K |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265899 |
|
|
|
|
| pmid |
sentence |
| 31226734 |
Vitamin K obtained from the diet is considered to reach the target tissues via lipid absorption and the transport system |
|
| Publications: |
1 |
| Pathways: | Vitamin-K cycle |
| + |
MC4R | down-regulates 
|
Food intake |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263504 |
|
|
Homo sapiens |
Hypothalamus |
| pmid |
sentence |
| 33094623 |
Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. Adipose tissue derived hormone leptin induces negative energy balance by stimulating α-MSH and melanocortin-4 receptor (MC4R) (Friedman 1997, Kask et al. 1998). Increased melanocortin signaling in hypotalamus leads not only to decreased food intake but also increases sympathetic nervous system outflow to skeletal muscle, energy expenditure and physical activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
Food intake | up-regulates quantity
|
vitamin D |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270565 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30080183 |
Ultraviolet radiation results in the conversion of 7-dehydrocholesterol to pre-vitamin D, which isomerizes to vitamin D in the skin. Vitamin D can also be obtained from nutrition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Vitamin-D Metabolism |
| + |
Food intake | up-regulates
|
folic acid |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19706381 |
The U.S. Reference Daily Intake (Daily Value) for FA is 0.4 mg for adults to aid in the prevention of birth defects and anemia, or double this amount for pregnant or lactating women. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | One-carbon Metabolism |
| + |
NPY | down-regulates
|
Food intake |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263505 |
|
|
Homo sapiens |
Hypothalamus |
| pmid |
sentence |
| 10195157 |
Neuropeptide Y (NPY) stimulates food intake and promotes weight gain, whereas melanocortins have the opposite effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
ACACA | down-regulates
|
Food intake |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263509 |
|
|
Homo sapiens |
Pulmonary Artery Smooth Muscle Cell |
| pmid |
sentence |
| 25343030 |
Leptin exerts an inhibitory effect on AMPK in the hypothalamus, thereby stimulating ACC and subsequently suppressing food intake. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
3.0
Food intake