4.0
Summary
| Name |  CBX3View Modifications |
| Full Name | Chromobox protein homolog 3 |
| Synonyms | HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein |
| Primary ID | Q13185 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates 
phosphorylation
|
CBX3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AURKA | up-regulates activity
phosphorylation
|
CBX3 | 0.361 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBX3 | up-regulates activity
binding
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBX3 | up-regulates activity
binding
|
NIPBL | 0.435 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBX3 | up-regulates activity
binding
|
H3-3A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBX3 | up-regulates activity
binding
|
H3-4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBX3 | form complex 
binding
|
ChAHP | 0.418 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | CBX3 | up-regulates activity
binding
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |