Summary

Name SLA
Full Name Src-like-adapter
Synonyms Src-like-adapter protein 1, SLAP-1, hSLAP | SLAP, SLAP1
Primary ID Q13239
Links - -
Type protein
Relations 5
Function Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation SLA 0.2
Publications: 3 Organism: Chlorocebus Aethiops
+ down-regulates quantity by destabilization img/direct_inhibition.png binding EPHA2 0.424
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination KIT 0.2
Publications: 1 Organism: Chlorocebus Aethiops