+ |
ITCH | down-regulates quantity by destabilization
polyubiquitination
|
LAPTM5 |
0.419 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272721 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
22009753 |
Here, we found that the level of LAPTM5 protein is regulated negatively by the degradation through ubiquitination by ITCH, an E3 ubiquitin ligase. ITCH directly binds to the PPxY motif of LAPTM5 via its WW domains and promotes ubiquitination through a HECT-type ligase domain. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NEDD4 | up-regulates activity
ubiquitination
|
LAPTM5 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278768 |
|
|
Homo sapiens |
|
pmid |
sentence |
17116753 |
These results suggest that LAPTM5 ubiquitination is mediated by Nedd4.|Thus, Nedd4 promotes the recruitment of GGA3 to LAPTM5, allowing LAPTM5 translocation from the Golgi to the lysosome with the aid of GGA3. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |