Summary

Name PMAIP1
Full Name Phorbol-12-myristate-13-acetate-induced protein 1
Synonyms PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa | NOXA
Primary ID Q13794
Links - -
Type protein
Relations 6
Function Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation PMAIP1 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PMAIP1 0.692
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination PMAIP1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PMAIP1 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PMAIP1 0.2
Publications: 1 Organism: Homo Sapiens