Summary

Name BMPR2
Full Name Bone morphogenetic protein receptor type-2
Synonyms BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II | PPH1
Primary ID Q13873
Links - -
Type protein
Relations 24
Pathways FAP: BMP, Osteoblast: BMP
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding BMPR2 0.559
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png binding BMPR2 0.585
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2 0.61
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png ubiquitination BMPR2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2 0.772
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination BMPR2 0.478
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BMPR2 0.571
Publications: 2 Organism: Gallus Gallus, Homo Sapiens
Tissue: Bone
+ up-regulates img/direct-activation.png binding ACVR1 0.695
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding ACVR1/BMPR2 0.695
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BMPR2 0.793
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png binding BMPR2 0.442
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2 0.798
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, phosphorylation BMPR1B 0.603
Publications: 2 Organism: Homo Sapiens
+ form complex img/form-complex.png binding BMPR1A/1B/2 0.607
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation, binding BMPR1A 0.61
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png ubiquitination BMPR2 0.54
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2 0.793
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BMPR1A 0.61
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding BMPR1B 0.603
Publications: 1 Organism: Chlorocebus Aethiops