3.0
Summary
| Name |  TRIM29View Modifications |
| Full Name | Tripartite motif-containing protein 29 |
| Synonyms | Ataxia telangiectasia group D-associated protein | ATDC |
| Primary ID | Q14134 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
phosphorylation