Summary

Name ATXN7L3
Full Name Ataxin-7-like protein 3
Synonyms SAGA-associated factor 11 homolog |
Primary ID Q14CW9
Links - -
Type protein
Relations 1
Function Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583).

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Relations

Regulator Mechanism target score ℹ
+ ATXN7L3form complex img/form-complex.png binding SAGA complex 0.76
Publications: 1 Organism: Homo Sapiens