Summary

Name TARBP2
Full Name RISC-loading complex subunit TARBP2
Synonyms TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein | TRBP
Primary ID Q15633
Links - -
Type protein
Relations 8
Function Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ RPS6KB1up-regulates activity img/direct-activation.png phosphorylation TARBP2 0.333
Publications: 2 Organism: In Vitro
+ AKT1up-regulates activity img/direct-activation.png phosphorylation TARBP2 0.2
Publications: 2 Organism: In Vitro
+ RPS6KB2up-regulates activity img/direct-activation.png phosphorylation TARBP2 0.345
Publications: 2 Organism: In Vitro
+ TARBP2up-regulates img/direct-activation.png binding DICER1 0.938
Publications: 1 Organism: Homo Sapiens
+ TARBP2form complex img/form-complex.png binding RISC(DICER1/AGO2/TARBP2) 0.9
Publications: 1 Organism: Homo Sapiens