3.0
Summary
| Name |  JMJD1CView Modifications |
| Full Name | Probable JmjC domain-containing histone demethylation protein 2C |
| Synonyms | Jumonji domain-containing protein 1C, Thyroid receptor-interacting protein 8, TR-interacting protein 8, TRIP-8 | JHDM2C, KIAA1380, TRIP8 |
| Primary ID | Q15652 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | JMJD1C | down-regulates activity 
demethylation
|
H3-3A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | JMJD1C | down-regulates activity
demethylation
|
H3-4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | JMJD1C | down-regulates activity
demethylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | mTORC1 | up-regulates activity 
phosphorylation
|
JMJD1C | 0.245 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USF1 | up-regulates activity
binding
|
JMJD1C | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Liver | |||
| + | JMJD1C | down-regulates activity
demethylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |