| + |
CLASP1 | up-regulates activity 
binding
|
MAPRE1 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265094 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15631994 |
CLIP-associating protein (CLASP) 1 and CLASP2 are mammalian microtubule (MT) plus-end binding proteins, which associate with CLIP-170 and CLIP-115.|We demonstrate that the middle part of CLASPs binds directly to EB1 and to MTs. | Both EB1- and cortex-binding domains of CLASP are required to promote MT stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEP43 | up-regulates
relocalization
|
MAPRE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142400 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16314388 |
Fop also binds to eb1 and is required for localizing eb1 to the centrosome |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPRE1 | up-regulates
binding
|
Microtubule_polimerization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264831 |
|
|
|
|
| pmid |
sentence |
| 17889670 |
Microtubule plus end binding proteins (+TIPs) localize to the dynamic plus ends of microtubules, where they stimulate microtubule growth and recruit signaling molecules. Three main +TIP classes have been identified (XMAP215, EB1, and CLIP-170) |
|
| Publications: |
1 |
| + |
CLASP2 | up-regulates activity
binding
|
MAPRE1 |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264829 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 19638411 |
GSK-3beta directly phosphorylates CLASP2 at Ser533 and Ser537 within the region responsible for the IQGAP1 binding. Phosphorylation of CLASP2 results in the dissociation of CLASP2 from IQGAP1, EB1 and microtubules.| CLASPs were originally identified as CLIP-170-interacting proteins and later found to be required for microtubule stabilisation at the cortical regions of epithelial cells |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
MAPRE1
- 
- 