Summary

Name UBE2V2
Full Name Ubiquitin-conjugating enzyme E2 variant 2
Synonyms DDVit 1, Enterocyte differentiation-associated factor 1, EDAF-1, Enterocyte differentiation-promoting factor 1, EDPF-1, MMS2 homolog, Vitamin D3-inducible protein | MMS2, UEV2
Primary ID Q15819
Links - -
Type protein
Relations 2
Function Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination UBE2V2 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination UBE2V2 0.544
Publications: 1 Organism: Homo Sapiens