| + |
USF2 | up-regulates quantity by expression 
transcriptional regulation
|
CTSD |
0.385 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255594 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 9731700 |
Overexpression of cathepsin D (CD), a ubiquitous lysosomal protease, is closely associated with a poor clinical outcome for patients with breast cancer. Estrogen greatly induces transcription of the CD gene in estrogen receptor (ER)-positive breast cancer cells. These experiments suggest a model for ER stimulation of the CD promoter in which recruitment of USF-1/2 to the promoter is required for activation of transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF2 | up-regulates quantity by expression
transcriptional regulation
|
FMR1 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254883 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11058604 |
We have also shown that USF1, USF2, and alpha-Pal/Nrf-1 are the major transcription factors that bind the promoter in brain and testis extracts and suggest that elevated levels of these factors account in part for elevated FMR1 expression in these organs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Brain |
| + |
GTF2I | up-regulates activity 
binding
|
USF2 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21282467 |
TFII-I has been shown to interact with USF and to associate with either E-box elements or initiator sequences to activate gene transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF2 | up-regulates quantity by expression
transcriptional regulation
|
MYH9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222608 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11467950 |
we have focused on element F of the NMHC-A gene. We have identified and characterized the factors which are capable of binding to element F. The basic helix_loop_helix leucine zipper (bHLH-LZ) proteins, TFEC-l and -s, which are alternatively spliced isoforms, TFE3, USF1, and USF2 have all been found to bind to element F with different binding activities and with different transcriptional activation potencies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USF2 | up-regulates quantity by expression
transcriptional regulation
|
B2M |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12480693 |
Here we show that upstream stimulatory factor 1 (USF1) and USF2 bind to the E box and regulate beta(2)m transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
USF2
- 
- 