4.0
Summary
| Name |  POU2AF1
|
| Full Name | POU domain class 2-associating factor 1 |
| Synonyms | B-cell-specific coactivator OBF-1, BOB-1, OCA-B, OCT-binding factor 1 | OBF1 |
| Primary ID | Q16633 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176). It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity). |
binding