+ |
TBR1 | up-regulates quantity by expression
transcriptional regulation
|
AUTS2 |
0.367 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266836 |
|
|
Mus musculus |
|
pmid |
sentence |
20615956 |
Tbr1 implements frontal identity in part by direct promoter binding and activation of Auts2, a frontal cortex gene implicated in autism. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Tissue: |
Brain |
+ |
TBR1 | up-regulates activity
binding
|
FOXP2 |
0.573 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266831 |
|
|
Homo sapiens |
|
pmid |
sentence |
25232744 |
We show that TBR1 homodimerizes, that it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and that this interaction is disrupted by pathogenic mutations affecting either protein. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TBR1 | down-regulates quantity by repression
transcriptional regulation
|
FEZF2 |
0.501 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268967 |
|
|
|
Neuron |
pmid |
sentence |
21228164 |
We found that TBR1 promotes the identity of corticothalamic neurons and represses subcerebral fates through reducing expression of Fezf2 and CTIP2.|(3) Chromatin immunoprecipitation analysis using TBR1 antibodies showed that TBR1 bound to a conserved region in the Fezf2 gene. |
|
Publications: |
1 |
+ |
CASK | up-regulates
binding
|
TBR1 |
0.471 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266835 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10749215 |
Here we report that, through its guanylate kinase domain, CASK interacts with Tbr-1, a T-box transcription factor that is involved in forebrain development. CASK enters the nucleus and binds to a specific DNA sequence (the T-element) in a complex with Tbr-1. CASK acts as a coactivator of Tbr-1 to induce transcription of T-element containing genes, including reelin, a gene that is essential for cerebrocortical development. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |