Summary

Name DGUOK
Full Name Deoxyguanosine kinase, mitochondrial
Synonyms dGK | DGK
Primary ID Q16854
Links - -
Type protein
Relations 8
Pathways Nucleotide Salvage
Function Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents.

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Relations

Regulator Mechanism target score ℹ
+ DGUOKdown-regulates quantity img/direct_inhibition.png chemical modification ATP(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ DGUOKup-regulates quantity img/direct-activation.png chemical modification 2'-deoxyguanosine 5'-monophosphate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
+ DGUOKup-regulates quantity img/direct-activation.png chemical modification ADP(3-) 0.8
Publications: 1 Organism: Homo Sapiens
+ DGUOKdown-regulates quantity img/direct_inhibition.png chemical modification 2'-deoxyadenosine 0.8
Publications: 1 Organism: Homo Sapiens
+ DGUOKup-regulates quantity img/direct-activation.png chemical modification 2'-deoxyadenosine 5'-monophosphate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
+ DGUOKdown-regulates quantity img/direct_inhibition.png chemical modification 2'-deoxyguanosine 0.8
Publications: 1 Organism: Homo Sapiens
+ DGUOKdown-regulates quantity img/direct_inhibition.png chemical modification 2'-deoxyinosine 0.8
Publications: 1 Organism: Homo Sapiens
+ DGUOKup-regulates quantity img/direct-activation.png chemical modification 2'-deoxyinosine 5'-phosphate(2-) 0.8
Publications: 1 Organism: Homo Sapiens