Relation Results

Summary

Name	KMT5B View Modifications
Full Name	Histone-lysine N-methyltransferase KMT5B
Synonyms	Lysine N-methyltransferase 5B, Lysine-specific methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1, Suv4-20h1, [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B, 2.1.1.362, [histone H4]-lysine20 N-methyltransferase KMT5B, 2.1.1.361 \| SUV420H1
Primary ID	Q4FZB7
Links	- -
Type	protein
Relations	3
Function	Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).