Summary

Name PDCD4
Full Name Programmed cell death protein 4
Synonyms Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a | H731
Primary ID Q53EL6
Links - -
Type protein
Relations 10
Function Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation PDCD4 0.441
Publications: 3 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png phosphorylation PDCD4 0.2
Publications: 3 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png phosphorylation PDCD4 0.595
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png phosphorylation PDCD4 0.445
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png ubiquitination PDCD4 0.434
Publications: 1 Organism: Homo Sapiens
Tissue: Skin