3.0
Summary
| Name |  PDCD4View Modifications |
| Full Name | Programmed cell death protein 4 |
| Synonyms | Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a | H731 |
| Primary ID | Q53EL6 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT1 | down-regulates 
phosphorylation
|
PDCD4 | 0.447 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| Tissue: | Skin | |||
| + | AKT | down-regulates
phosphorylation
|
PDCD4 | 0.2 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| Tissue: | Skin | |||
| + | RPS6KB1 | down-regulates
phosphorylation
|
PDCD4 | 0.598 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Tissue: | Skin | |||
| + | RPS6KB2 | down-regulates
phosphorylation
|
PDCD4 | 0.45 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Skin | |||
| + | BTRC | down-regulates
ubiquitination
|
PDCD4 | 0.435 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Skin | |||