Summary

Name DACT2
Full Name Dapper homolog 2
Synonyms Dapper antagonist of catenin 2 | C6orf116
Primary ID Q5SW24
Links - -
Type protein
Relations 1
Function Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).

Viewer

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png binding TGFBR1 0.405
Publications: 1 Organism: Homo Sapiens