Summary

Name TGFBR1
Full Name TGF-beta receptor type-1
Synonyms TGFR-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ALK-5, ALK5, Serine/threonine-protein kinase receptor R4, SKR4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I | ALK5, SKR4
Primary ID P36897
Links - -
Type protein
Relations 53
Pathways Macrophage: TGF beta, FAP: BMP, P38 Signaling, TGFbeta Signaling, Cell cycle: G1/S phase transition, Adipogenesis, Colorectal Carcinoma, FAP: TGF beta, Thyroid cancer, T-Lymphocyte: TGF beta
Inhibitors 700874-72-2; SB-505124; 356559-20-1; 301836-41-9; 452342-67-5
Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation TP63 0.19
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TGFBR1
Publications: 4 Organism: Homo Sapiens
Pathways:FAP: TGF beta, TGFbeta Signaling
+ down-regulates img/direct_inhibition.png phosphorylation EEF1A1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD3
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis, Colorectal Carcinoma, FAP: BMP, FAP: TGF beta, Cell cycle: G1/S phase transition, Macrophage: TGF beta, Thyroid cancer, TGFbeta Signaling, T-Lymphocyte: TGF beta
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.90
Publications: 3 Organism: Homo Sapiens
Pathways:FAP: BMP, Macrophage: TGF beta, TGFbeta Signaling, T-Lymphocyte: TGF beta
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TGFBR1
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Colorectal Carcinoma, FAP: BMP, FAP: TGF beta, Cell cycle: G1/S phase transition, Macrophage: TGF beta, P38 Signaling, Thyroid cancer, TGFbeta Signaling, T-Lymphocyte: TGF beta
+ up-regulates img/direct-activation.png binding TGFBR1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation TGFBR1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TGFBR1
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates img/direct-activation.png binding PI3K
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR1
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR1
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR1
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: BMP
+ up-regulates img/direct-activation.png unknown SMAD3 0.83
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Colorectal Carcinoma, FAP: BMP, FAP: TGF beta, Cell cycle: G1/S phase transition, Macrophage: TGF beta, Thyroid cancer, TGFbeta Signaling, T-Lymphocyte: TGF beta
+ up-regulates activity img/direct-activation.png unknown RAC1 0.20
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR1 0.60
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Colorectal Carcinoma, FAP: BMP, FAP: TGF beta, Cell cycle: G1/S phase transition, Macrophage: TGF beta, P38 Signaling, Thyroid cancer, TGFbeta Signaling, T-Lymphocyte: TGF beta
+ up-regulates img/direct-activation.png phosphorylation TGFBR1 1.00
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: TGF beta, TGFbeta Signaling
+ up-regulates img/direct-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Colorectal Carcinoma, Thyroid cancer
+ down-regulates img/direct_inhibition.png ubiquitination TGFBR1 0.37
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TGFBR1 0.82
Publications: 2 Organism: Homo Sapiens
Pathways:FAP: BMP, TGFbeta Signaling
+ up-regulates activity img/direct-activation.png binding TRAF6 0.34
Publications: 2 Organism: Homo Sapiens
Tissue: HEK-293T Cell
Pathways:FAP: BMP, P38 Signaling, TGFbeta Signaling
+ up-regulates activity img/direct-activation.png unknown RHOA 0.23
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.20
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png binding TGFBR1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3R2 0.23
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3R1 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TGFBR1 0.69
Publications: 2 Organism: Homo Sapiens
Pathways:FAP: BMP, TGFbeta Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZFYVE9 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage: TGF beta, TGFbeta Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation SPTBN1 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR1 0.26
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png stabilization TGFBR1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR1
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ down-regulates img/direct_inhibition.png binding TGFBR1
Publications: 1 Organism: Homo Sapiens